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Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial.

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Title: Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial.
Authors: Tadié JM; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France. jeanmarc.tadie@chu-rennes.fr.; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France. jeanmarc.tadie@chu-rennes.fr.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France. jeanmarc.tadie@chu-rennes.fr., Ouattara A; Department of Cardiovascular Anaesthesia and Critical Care, CHU Bordeaux, Magellan Medico-Surgical Centre, Bordeaux, France.; UMR 1034, Biology of Cardiovascular Diseases, Univ. Bordeaux, INSERM, Pessac, France., Laviolle B; CHU Rennes, Univ Rennes, Inserm, UMR_S 1085 (IRSET), CIC 1414, Rennes, France., Lesouhaitier M; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France., Esvan M; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France., Rousseau C; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France., Grégoire M; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France., Gaudriot B; Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, France., Nesseler N; Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, France., Labaste F; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Sanchez P; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Marcheix B; Department of Cardiovascular Surgery, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Beurton A; Department of Cardiovascular Anaesthesia and Critical Care, CHU Bordeaux, Magellan Medico-Surgical Centre, Bordeaux, France.; UMR 1034, Biology of Cardiovascular Diseases, Univ. Bordeaux, INSERM, Pessac, France., Dureau P; Department of Anesthesiology and Critical Care Medicine, Sorbonne University, Cardiology Institute, GRC 29, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France., Demondion P; Thoracic and Cardiovascular Surgery Department, Groupe Hospitalier Pitié-Salpétrière, Institute of Cardiology, Sorbonne Université, APHP, Paris, France., Fouquet O; Department of Cardiac Surgery, University Hospital of Angers, Angers, France., Rineau E; Department of Anesthesiology and Critical Care, Angers University, Angers, France., Amour J; Institute of Perfusion, Critical Care Medicine and Anesthesiology in Cardiac Surgery Paris Sud (IPRA), Hôpital Privé Jacques Cartier, Ramsay Health Care, Massy, France., Verhoye JP; Department of Vascular and Cardio-Thoracic Surgery, Rennes University Hospital, Rennes, France., Mercat A; Medical Intensive Care Unit, Vent'Lab, Angers University Hospital, University of Angers, 4 Rue Larrey, Angers, France., Terzi N; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France., Tarte K; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France., Bouglé A; Department of Anesthesiology and Critical Care Medicine, Sorbonne University, Cardiology Institute, GRC 29, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France., Flecher E; Department of Vascular and Cardio-Thoracic Surgery, Rennes University Hospital, Rennes, France.
Corporate Authors: VECAR Trial Group and REVA
Source: Intensive care medicine [Intensive Care Med] 2025 May; Vol. 51 (5), pp. 849-860. Date of Electronic Publication: 2025 May 05.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Tadié+JM%22">Tadié JM</searchLink>; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France. jeanmarc.tadie@chu-rennes.fr.; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France. jeanmarc.tadie@chu-rennes.fr.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France. jeanmarc.tadie@chu-rennes.fr.<br /><searchLink fieldCode="AU" term="%22Ouattara+A%22">Ouattara A</searchLink>; Department of Cardiovascular Anaesthesia and Critical Care, CHU Bordeaux, Magellan Medico-Surgical Centre, Bordeaux, France.; UMR 1034, Biology of Cardiovascular Diseases, Univ. Bordeaux, INSERM, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Laviolle+B%22">Laviolle B</searchLink>; CHU Rennes, Univ Rennes, Inserm, UMR_S 1085 (IRSET), CIC 1414, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Lesouhaitier+M%22">Lesouhaitier M</searchLink>; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Esvan+M%22">Esvan M</searchLink>; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Rousseau+C%22">Rousseau C</searchLink>; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Grégoire+M%22">Grégoire M</searchLink>; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Gaudriot+B%22">Gaudriot B</searchLink>; Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Nesseler+N%22">Nesseler N</searchLink>; Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Labaste+F%22">Labaste F</searchLink>; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Sanchez+P%22">Sanchez P</searchLink>; Anesthesiology and Intensive Care Department, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Marcheix+B%22">Marcheix B</searchLink>; Department of Cardiovascular Surgery, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Beurton+A%22">Beurton A</searchLink>; Department of Cardiovascular Anaesthesia and Critical Care, CHU Bordeaux, Magellan Medico-Surgical Centre, Bordeaux, France.; UMR 1034, Biology of Cardiovascular Diseases, Univ. Bordeaux, INSERM, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Dureau+P%22">Dureau P</searchLink>; Department of Anesthesiology and Critical Care Medicine, Sorbonne University, Cardiology Institute, GRC 29, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Demondion+P%22">Demondion P</searchLink>; Thoracic and Cardiovascular Surgery Department, Groupe Hospitalier Pitié-Salpétrière, Institute of Cardiology, Sorbonne Université, APHP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fouquet+O%22">Fouquet O</searchLink>; Department of Cardiac Surgery, University Hospital of Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Rineau+E%22">Rineau E</searchLink>; Department of Anesthesiology and Critical Care, Angers University, Angers, France.<br /><searchLink fieldCode="AU" term="%22Amour+J%22">Amour J</searchLink>; Institute of Perfusion, Critical Care Medicine and Anesthesiology in Cardiac Surgery Paris Sud (IPRA), Hôpital Privé Jacques Cartier, Ramsay Health Care, Massy, France.<br /><searchLink fieldCode="AU" term="%22Verhoye+JP%22">Verhoye JP</searchLink>; Department of Vascular and Cardio-Thoracic Surgery, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Mercat+A%22">Mercat A</searchLink>; Medical Intensive Care Unit, Vent'Lab, Angers University Hospital, University of Angers, 4 Rue Larrey, Angers, France.<br /><searchLink fieldCode="AU" term="%22Terzi+N%22">Terzi N</searchLink>; Department of Infectious Diseases and Intensive Care Unit, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.; Centre d'investigation Clinique de Rennes (CIC1414), Inserm, Centre Hospitalier Universitaire Rennes, Université de Rennes 1, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Tarte+K%22">Tarte K</searchLink>; SITI Laboratory, UMR U1236, INSERM, University of Rennes, EFS, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bouglé+A%22">Bouglé A</searchLink>; Department of Anesthesiology and Critical Care Medicine, Sorbonne University, Cardiology Institute, GRC 29, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Flecher+E%22">Flecher E</searchLink>; Department of Vascular and Cardio-Thoracic Surgery, Rennes University Hospital, Rennes, France.
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