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Enhanced pain relief with guanfacine as an adjuvant for trigeminal nerve blocks: insights from a PheWAS-guided randomized controlled study.

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Title: Enhanced pain relief with guanfacine as an adjuvant for trigeminal nerve blocks: insights from a PheWAS-guided randomized controlled study.
Authors: Meier SE; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States., Orr MB; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States., Shotwell MS; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203-1741, United States., Jerome RN; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States., Shirey-Rice JK; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States., Pulley JM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States., Edwards DA; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States., Toye AD; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States., Mishra P; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States., Kesayan T; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Source: Pain medicine (Malden, Mass.) [Pain Med] 2025 Oct 01; Vol. 26 (10), pp. 643-654.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: published by Oxford University Press on behalf of the American Academy of Pain Medicine Country of Publication: England NLM ID: 100894201 Publication Model: Print Cited Medium: Internet ISSN: 1526-4637 (Electronic) Linking ISSN: 15262375 NLM ISO Abbreviation: Pain Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhanced pain relief with guanfacine as an adjuvant for trigeminal nerve blocks: insights from a PheWAS-guided randomized controlled study.
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  Data: <searchLink fieldCode="AU" term="%22Meier+SE%22">Meier SE</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States.<br /><searchLink fieldCode="AU" term="%22Orr+MB%22">Orr MB</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States.<br /><searchLink fieldCode="AU" term="%22Shotwell+MS%22">Shotwell MS</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203-1741, United States.<br /><searchLink fieldCode="AU" term="%22Jerome+RN%22">Jerome RN</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States.<br /><searchLink fieldCode="AU" term="%22Shirey-Rice+JK%22">Shirey-Rice JK</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States.<br /><searchLink fieldCode="AU" term="%22Pulley+JM%22">Pulley JM</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203-8820, United States.<br /><searchLink fieldCode="AU" term="%22Edwards+DA%22">Edwards DA</searchLink>; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States.<br /><searchLink fieldCode="AU" term="%22Toye+AD%22">Toye AD</searchLink>; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States.<br /><searchLink fieldCode="AU" term="%22Mishra+P%22">Mishra P</searchLink>; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States.<br /><searchLink fieldCode="AU" term="%22Kesayan+T%22">Kesayan T</searchLink>; Division of Pain Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37204, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22published+by+Oxford+University+Press+on+behalf+of+the+American+Academy+of+Pain+Medicine%22">published by Oxford University Press on behalf of the American Academy of Pain Medicine </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100894201 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1526-4637 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215262375%22">15262375 </searchLink><i>NLM ISO Abbreviation: </i>Pain Med <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct 01
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