Rationale and design of a randomised phase II multicentre crossover trial investigating a sodium-glucose co-transporter 2 inhibitor, dapagliflozin, combined with a novel continuous ketone monitor in adults with type 1 diabetes to reduce the risk of diabetic ketoacidosis: the PARTNER study.
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| Title: | Rationale and design of a randomised phase II multicentre crossover trial investigating a sodium-glucose co-transporter 2 inhibitor, dapagliflozin, combined with a novel continuous ketone monitor in adults with type 1 diabetes to reduce the risk of diabetic ketoacidosis: the PARTNER study. |
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| Authors: | Ngan J; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., Kong YW; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia., Goad J; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., Huang MLH; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Jenkins A; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia., Vogrin S; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., Trawley S; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.; Cairnmillar Institute, Hawthorn, Victoria, Australia., Manzoney A; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia., Nakano M; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia., Ekinci E; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia., Kriketos A; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia., Fourlanos S; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Boisseau L; Department of Diabetes and Endocrinology, Canberra Health Services, Garran, Canberra, Australia., Nolan CJ; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Diabetes and Endocrinology, Canberra Health Services, Garran, Canberra, Australia.; School of Medicine and Psychology, Australian National University, Acton, Canberra, Australia., Taylor P; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia., Fenn J; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia., Stranks SN; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia., O'Neal DN; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia dno@unimelb.edu.au.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia. |
| Source: | BMJ open [BMJ Open] 2025 May 06; Vol. 15 (5), pp. e098457. Date of Electronic Publication: 2025 May 06. |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40328646 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rationale and design of a randomised phase II multicentre crossover trial investigating a sodium-glucose co-transporter 2 inhibitor, dapagliflozin, combined with a novel continuous ketone monitor in adults with type 1 diabetes to reduce the risk of diabetic ketoacidosis: the PARTNER study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ngan+J%22">Ngan J</searchLink>; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kong+YW%22">Kong YW</searchLink>; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Goad+J%22">Goad J</searchLink>; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+MLH%22">Huang MLH</searchLink>; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Jenkins+A%22">Jenkins A</searchLink>; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Vogrin+S%22">Vogrin S</searchLink>; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Trawley+S%22">Trawley S</searchLink>; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.; Cairnmillar Institute, Hawthorn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Manzoney+A%22">Manzoney A</searchLink>; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Nakano+M%22">Nakano M</searchLink>; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ekinci+E%22">Ekinci E</searchLink>; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Endocrinology and Centre for Research in Education in Diabetes and Obesity, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kriketos+A%22">Kriketos A</searchLink>; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fourlanos+S%22">Fourlanos S</searchLink>; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Boisseau+L%22">Boisseau L</searchLink>; Department of Diabetes and Endocrinology, Canberra Health Services, Garran, Canberra, Australia.<br /><searchLink fieldCode="AU" term="%22Nolan+CJ%22">Nolan CJ</searchLink>; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia.; Department of Diabetes and Endocrinology, Canberra Health Services, Garran, Canberra, Australia.; School of Medicine and Psychology, Australian National University, Acton, Canberra, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+P%22">Taylor P</searchLink>; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Fenn+J%22">Fenn J</searchLink>; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Stranks+SN%22">Stranks SN</searchLink>; Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neal+DN%22">O'Neal DN</searchLink>; Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia dno@unimelb.edu.au.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Australian Centre for Accelerating Diabetes Innovations, School of Medicine, University of Melbourne, Parkville, Victoria, Australia. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 May 06; Vol. 15 (5), pp. e098457. <i>Date of Electronic Publication: </i>2025 May 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial Protocol; Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101552874 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-6055 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220446055%22">20446055 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40328646 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/bmjopen-2024-098457 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e098457 Titles: – TitleFull: Rationale and design of a randomised phase II multicentre crossover trial investigating a sodium-glucose co-transporter 2 inhibitor, dapagliflozin, combined with a novel continuous ketone monitor in adults with type 1 diabetes to reduce the risk of diabetic ketoacidosis: the PARTNER study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ngan J – PersonEntity: Name: NameFull: Kong YW – PersonEntity: Name: NameFull: Goad J – PersonEntity: Name: NameFull: Huang MLH – PersonEntity: Name: NameFull: Jenkins A – PersonEntity: Name: NameFull: Vogrin S – PersonEntity: Name: NameFull: Trawley S – PersonEntity: Name: NameFull: Manzoney A – PersonEntity: Name: NameFull: Nakano M – PersonEntity: Name: NameFull: Ekinci E – PersonEntity: Name: NameFull: Kriketos A – PersonEntity: Name: NameFull: Fourlanos S – PersonEntity: Name: NameFull: Boisseau L – PersonEntity: Name: NameFull: Nolan CJ – PersonEntity: Name: NameFull: Taylor P – PersonEntity: Name: NameFull: Fenn J – PersonEntity: Name: NameFull: Stranks SN – PersonEntity: Name: NameFull: O'Neal DN IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 05 Text: 2025 May 06 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2044-6055 Numbering: – Type: volume Value: 15 – Type: issue Value: 5 Titles: – TitleFull: BMJ open Type: main |
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