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TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression.

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Title: TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression.
Authors: Crump KB; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012, Bern, Switzerland., Kanelis E; School of Mechanical Engineering, National Technical University of Athens, 15772, Zografou, Greece.; Protavio Ltd, 15341, Agia Paraskevi, Greece., Segarra-Queralt M; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain., Pascuet-Fontanet A; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain., Bermudez-Lekerika P; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012, Bern, Switzerland., Alminnawi A; GIGA In Silico Medicine, University of Liège, Liège, 4000, Belgium.; Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Leuven, Belgium., Geris L; GIGA In Silico Medicine, University of Liège, Liège, 4000, Belgium.; Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Leuven, Belgium., Alexopoulos LG; School of Mechanical Engineering, National Technical University of Athens, 15772, Zografou, Greece.; Protavio Ltd, 15341, Agia Paraskevi, Greece., Noailly J; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain., Gantenbein B; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland. Benjamin.Gantenbein@unibe.ch.; Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Faculty of Medicine, University of Bern, 3010, Bern, Switzerland. Benjamin.Gantenbein@unibe.ch.
Source: Scientific reports [Sci Rep] 2025 May 06; Vol. 15 (1), pp. 15849. Date of Electronic Publication: 2025 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Crump+KB%22">Crump KB</searchLink>; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kanelis+E%22">Kanelis E</searchLink>; School of Mechanical Engineering, National Technical University of Athens, 15772, Zografou, Greece.; Protavio Ltd, 15341, Agia Paraskevi, Greece.<br /><searchLink fieldCode="AU" term="%22Segarra-Queralt+M%22">Segarra-Queralt M</searchLink>; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pascuet-Fontanet+A%22">Pascuet-Fontanet A</searchLink>; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bermudez-Lekerika+P%22">Bermudez-Lekerika P</searchLink>; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Alminnawi+A%22">Alminnawi A</searchLink>; GIGA In Silico Medicine, University of Liège, Liège, 4000, Belgium.; Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Geris+L%22">Geris L</searchLink>; GIGA In Silico Medicine, University of Liège, Liège, 4000, Belgium.; Skeletal Biology and Engineering Research Center, KU Leuven, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Alexopoulos+LG%22">Alexopoulos LG</searchLink>; School of Mechanical Engineering, National Technical University of Athens, 15772, Zografou, Greece.; Protavio Ltd, 15341, Agia Paraskevi, Greece.<br /><searchLink fieldCode="AU" term="%22Noailly+J%22">Noailly J</searchLink>; BCN Medtech, Universitat Pompeu Fabra, 08018, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gantenbein+B%22">Gantenbein B</searchLink>; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, 3008, Bern, Switzerland. Benjamin.Gantenbein@unibe.ch.; Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Faculty of Medicine, University of Bern, 3010, Bern, Switzerland. Benjamin.Gantenbein@unibe.ch.
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