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The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients.

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Title: The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients.
Authors: Mayerhöfer T; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria., Joannidis M; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria., Klein S; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.; Karl Landsteiner University of Health Sciences, Krems, Austria.; Department of Internal Medicine 2, University Hospital St. Pölten, St. Pölten, Austria., Franke A; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany., Margarita S; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ronzoni L; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Pertler E; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria., Wagner S; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria., Sahanic S; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Haschka D; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Hochhold C; Department of Anesthesiology and Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria., Treml B; Department of Anesthesiology and Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria., Valenti L; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Tilg H; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria., Schaefer B; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. benedikt.schaefer@i-med.ac.at., Zoller H; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
Source: Scientific reports [Sci Rep] 2025 May 06; Vol. 15 (1), pp. 15802. Date of Electronic Publication: 2025 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients.
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  Data: <searchLink fieldCode="AU" term="%22Mayerhöfer+T%22">Mayerhöfer T</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Joannidis+M%22">Joannidis M</searchLink>; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Klein+S%22">Klein S</searchLink>; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.; Karl Landsteiner University of Health Sciences, Krems, Austria.; Department of Internal Medicine 2, University Hospital St. Pölten, St. Pölten, Austria.<br /><searchLink fieldCode="AU" term="%22Franke+A%22">Franke A</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Margarita+S%22">Margarita S</searchLink>; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ronzoni+L%22">Ronzoni L</searchLink>; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pertler+E%22">Pertler E</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Sahanic+S%22">Sahanic S</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Tancevski+I%22">Tancevski I</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Haschka+D%22">Haschka D</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Hochhold+C%22">Hochhold C</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Treml+B%22">Treml B</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Valenti+L%22">Valenti L</searchLink>; Precision Medicine Lab, Biological Resource Center - Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tilg+H%22">Tilg H</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Schaefer+B%22">Schaefer B</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. benedikt.schaefer@i-med.ac.at.<br /><searchLink fieldCode="AU" term="%22Zoller+H%22">Zoller H</searchLink>; Department of Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Christian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Innsbruck, Austria.
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