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Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study.

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Title: Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study.
Authors: Arellano ML; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA., Thirman MJ; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., DiPersio JF; Department of Medicine, Washington University School of Medicine, St Louis, MO., Heiblig M; Hematology Department, Centre Hospitalier Lyon Sud, Lyon, France., Stein EM; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Schuh AC; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada., Žučenka A; Faculty of Medicine, Hematology and Oncology Department, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania., de Botton S; Hematologie Clinique, Institut Gustave Roussy, Villejuif, France., Grove CS; Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.; Department of Haematology, PathWest Inc, Nedlands, WA, Australia.; Department of Haematology, University of Western Australia, Nedlands, WA, Australia., Mannis GN; Division of Hematology, Stanford University School of Medicine, Stanford, CA., Papayannidis C; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli,' Bologna, Italy., Perl AE; Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA., Issa GC; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Aldoss I; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA., Bajel A; Department of Haematology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.; Department of Haematology, The Royal Melbourne Hospital, Melbourne, VIC, Australia., Dickens DS; Division of Pediatric Hematology/Oncology, University of Iowa Stead Family Children's Hospital, Iowa City, IA., Kühn MWM; Department of Hematology and Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany., Mantzaris I; Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY., Raffoux E; Adult Hematology Department, Hospital Saint Louis, Université Paris Diderot, Paris, France., Traer E; Division of Hematology/Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR., Amitai I; Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel.; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Döhner H; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Greco C; Division of Hematology, Ospedale San Bortolo, Aulss Berica, Vicenza, Italy., Kovacsovics T; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Phoenix, Goodyear, AZ., McMahon CM; Department of Hematology, University of Colorado School of Medicine, Aurora, CO., Montesinos P; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain., Pigneux A; Hematology Department, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France., Shami PJ; Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT., Stone RM; Department of Medical Oncology, Division of Leukemia, Dana-Farber Cancer Institute, Boston, MA., Wolach O; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Israel., Harpel JG; ICON plc, New York, NY., Chudnovsky Y; Syndax Pharmaceuticals, Inc, Waltham, MA., Yu L; Syndax Pharmaceuticals, Inc, Waltham, MA., Bagley RG; Syndax Pharmaceuticals, Inc, Waltham, MA., Smith AR; Syndax Pharmaceuticals, Inc, Waltham, MA., Blachly JS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
Source: Blood [Blood] 2025 Aug 28; Vol. 146 (9), pp. 1065-1077.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study.
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  Data: <searchLink fieldCode="AU" term="%22Arellano+ML%22">Arellano ML</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Thirman+MJ%22">Thirman MJ</searchLink>; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22DiPersio+JF%22">DiPersio JF</searchLink>; Department of Medicine, Washington University School of Medicine, St Louis, MO.<br /><searchLink fieldCode="AU" term="%22Heiblig+M%22">Heiblig M</searchLink>; Hematology Department, Centre Hospitalier Lyon Sud, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Stein+EM%22">Stein EM</searchLink>; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Schuh+AC%22">Schuh AC</searchLink>; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Žučenka+A%22">Žučenka A</searchLink>; Faculty of Medicine, Hematology and Oncology Department, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.<br /><searchLink fieldCode="AU" term="%22de+Botton+S%22">de Botton S</searchLink>; Hematologie Clinique, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Grove+CS%22">Grove CS</searchLink>; Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.; Department of Haematology, PathWest Inc, Nedlands, WA, Australia.; Department of Haematology, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Mannis+GN%22">Mannis GN</searchLink>; Division of Hematology, Stanford University School of Medicine, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Papayannidis+C%22">Papayannidis C</searchLink>; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli,' Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Perl+AE%22">Perl AE</searchLink>; Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Issa+GC%22">Issa GC</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Aldoss+I%22">Aldoss I</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA.<br /><searchLink fieldCode="AU" term="%22Bajel+A%22">Bajel A</searchLink>; Department of Haematology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.; Department of Haematology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dickens+DS%22">Dickens DS</searchLink>; Division of Pediatric Hematology/Oncology, University of Iowa Stead Family Children's Hospital, Iowa City, IA.<br /><searchLink fieldCode="AU" term="%22Kühn+MWM%22">Kühn MWM</searchLink>; Department of Hematology and Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mantzaris+I%22">Mantzaris I</searchLink>; Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY.<br /><searchLink fieldCode="AU" term="%22Raffoux+E%22">Raffoux E</searchLink>; Adult Hematology Department, Hospital Saint Louis, Université Paris Diderot, Paris, France.<br /><searchLink fieldCode="AU" term="%22Traer+E%22">Traer E</searchLink>; Division of Hematology/Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Amitai+I%22">Amitai I</searchLink>; Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel.; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Döhner+H%22">Döhner H</searchLink>; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Greco+C%22">Greco C</searchLink>; Division of Hematology, Ospedale San Bortolo, Aulss Berica, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Kovacsovics+T%22">Kovacsovics T</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Phoenix, Goodyear, AZ.<br /><searchLink fieldCode="AU" term="%22McMahon+CM%22">McMahon CM</searchLink>; Department of Hematology, University of Colorado School of Medicine, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Montesinos+P%22">Montesinos P</searchLink>; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Pigneux+A%22">Pigneux A</searchLink>; Hematology Department, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Shami+PJ%22">Shami PJ</searchLink>; Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT.<br /><searchLink fieldCode="AU" term="%22Stone+RM%22">Stone RM</searchLink>; Department of Medical Oncology, Division of Leukemia, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Wolach+O%22">Wolach O</searchLink>; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petach Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Harpel+JG%22">Harpel JG</searchLink>; ICON plc, New York, NY.<br /><searchLink fieldCode="AU" term="%22Chudnovsky+Y%22">Chudnovsky Y</searchLink>; Syndax Pharmaceuticals, Inc, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Syndax Pharmaceuticals, Inc, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Bagley+RG%22">Bagley RG</searchLink>; Syndax Pharmaceuticals, Inc, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Smith+AR%22">Smith AR</searchLink>; Syndax Pharmaceuticals, Inc, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Blachly+JS%22">Blachly JS</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
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