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A phase 1/2a clinical trial to assess safety and immunogenicity of an adenoviral-vectored capsular group B meningococcal vaccine.

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Title: A phase 1/2a clinical trial to assess safety and immunogenicity of an adenoviral-vectored capsular group B meningococcal vaccine.
Authors: Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Oguti B; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.; Division of Infection and Immunity, Faculty of Medical Sciences, University College London, London WC1E 6JF, UK., Silva-Reyes L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Stanzelova A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Raymond M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Smith CC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Moore M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Barton A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Choi EM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Tanha K; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Louth J; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK., Holland A; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK., Cook R; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK., King J; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK., Lucidarme J; Meningococcal Reference Unit, UK Health Security Agency, Manchester M13 9WL, UK., Borrow R; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.; Meningococcal Reference Unit, UK Health Security Agency, Manchester M13 9WL, UK., Hill AVS; Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Beernink PT; Department of Paediatrics, University of California, San Francisco, San Francisco, CA 94143, USA., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK., Rollier CS; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.; School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Source: Science translational medicine [Sci Transl Med] 2025 May 07; Vol. 17 (797), pp. eadn1441. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 1/2a clinical trial to assess safety and immunogenicity of an adenoviral-vectored capsular group B meningococcal vaccine.
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  Data: <searchLink fieldCode="AU" term="%22Dold+C%22">Dold C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Oguti+B%22">Oguti B</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.; Division of Infection and Immunity, Faculty of Medical Sciences, University College London, London WC1E 6JF, UK.<br /><searchLink fieldCode="AU" term="%22Silva-Reyes+L%22">Silva-Reyes L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Stanzelova+A%22">Stanzelova A</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Raymond+M%22">Raymond M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Smith+CC%22">Smith CC</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Moore+M%22">Moore M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Barton+A%22">Barton A</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Choi+EM%22">Choi EM</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Plested+E%22">Plested E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Tanha+K%22">Tanha K</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Louth+J%22">Louth J</searchLink>; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Holland+A%22">Holland A</searchLink>; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Cook+R%22">Cook R</searchLink>; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22King+J%22">King J</searchLink>; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Lucidarme+J%22">Lucidarme J</searchLink>; Meningococcal Reference Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Borrow+R%22">Borrow R</searchLink>; Vaccine Evaluation Unit, UK Health Security Agency, Manchester M13 9WL, UK.; Meningococcal Reference Unit, UK Health Security Agency, Manchester M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Beernink+PT%22">Beernink PT</searchLink>; Department of Paediatrics, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+AJ%22">Pollard AJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.<br /><searchLink fieldCode="AU" term="%22Rollier+CS%22">Rollier CS</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford OX37LE, UK.; School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 May 07; Vol. 17 (797), pp. eadn1441. <i>Date of Electronic Publication: </i>2025 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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