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Real-life effectiveness and safety of tofacitinib and vedolizumab as 2nd-line for ulcerative colitis after anti-TNFs: A multicenter cohort IGIBD study (VE2TO-UC).

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Title: Real-life effectiveness and safety of tofacitinib and vedolizumab as 2nd-line for ulcerative colitis after anti-TNFs: A multicenter cohort IGIBD study (VE2TO-UC).
Authors: Noviello D; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy., Fries W; University of Messina, Dept. of Clinical and Experimental Medicine, Messina, Italy., Orlando A; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy., Conforti FS; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy., Bezzio C; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy., Castiglione F; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy., Fantini MC; University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy., Savarino EV; University of Padua, Department of Surgery- Oncology and Gastroenterology, Padova, Italy., Festa S; 'San Filippo Neri' Hospital, IBD Unit, Roma, Italy., Ribaldone DG; University of Turin, Department of Medical Sciences, Torino, Italy., Mocci G; Azienda Ospedaliera ARNAS G. Brotzu, SC Gastroenterologia, Cagliari, Italy., Grossi L; 'G d'Annunzio' University, Gastroenterology Unit- 'Spirito Santo' Hospital, Pescara, Italy., Viganò C; Division of Gastroenterology- Center for Autoimmune Liver Diseases- Department of Medicine and Surgery- University of Milano-Bicocca; European Reference Network on Hepatological Diseases ERN RARE-LIVER- Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Imperatore N; Gastroenterology and Endoscopy Unit, Santa Maria delle Grazie Hospital, Napoli, Italy., Ceccarelli L; Azienda Ospedaliero Universitaria Pisana, Gastroenterology Unit, Pisa, Italy., Gabrielli AMC; ASST Fatebenefratelli-Sacco- Milano, Gastroenterology and Endoscopy Unit, Milano, Italy., Scardino G; 'Valduce' Hospital, Gastroenterology Department, Como, Italy., Saibeni S; IBD Centre, Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho, Italy., Balestrieri P; Gastroenterology Unit, Fondazione Policlinico Campus Bio-Medico, Rome, Italy., Principi M; University of Bari, Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J- Gastroenterology Unit, Bari, Italy., Campigotto M; ASUGI- Ospedale di Cattinara, Gastroenterologia ed Endoscopia Digestiva, Trieste, Italy., Gravina AG; University of Campania Luigi Vanvitelli, Department of Precision Medicine- Hepatogastroenterology Unit, Napoli, Italy., Spagnuolo R; Dipartimento di Scienze della Salute Università 〈Magna Graecia〉 Catanzaro., Scaldaferri F; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS- IBD Unit- CEMAD- Digestive Diseases Center- Medicina Interna e Gastroenterologia, Roma, Italy; Dipartimento di medicina e chirurgia Traslazionale - Università cattolica del Sacro Cuore- Roma, Roma, Italy., Neri B; University 'Tor Vergata' of Rome, Department of Systems Medicine, Roma, Italy., Sario AD; Unità di Gastroenterologia ed Endoscopia Digestiva, Ospedale di Senigallia, AST Ancona., Baldoni M; SC Gastroenterologia ed Endoscopia Digestiva AO-Universitaria di Perugia Dipartimento di Medicina e Chirurgia., Mitri RD; Gastroenterology and Endoscopy Unit, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Italy., Tettoni E; Gastroenterology and Digestive Endoscopy Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Calderone S; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy., Armuzzi A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy., Macaluso FS; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy., Vecchi M; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy., Ventimiglia M; Italian Ministry of Health, Directorate General of Medical Device and Pharmaceutical Service, Roma, Italy; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy., Caprioli F; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy. Electronic address: flavio.caprioli@unimi.it.
Corporate Authors: VE2TO-UC study group
Source: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2025 Jul; Vol. 57 (7), pp. 1419-1427. Date of Electronic Publication: 2025 May 06.
Publication Type: Journal Article; Multicenter Study; Observational Study; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100958385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3562 (Electronic) Linking ISSN: 15908658 NLM ISO Abbreviation: Dig Liver Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Real-life effectiveness and safety of tofacitinib and vedolizumab as 2nd-line for ulcerative colitis after anti-TNFs: A multicenter cohort IGIBD study (VE2TO-UC).
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  Data: <searchLink fieldCode="AU" term="%22Noviello+D%22">Noviello D</searchLink>; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Fries+W%22">Fries W</searchLink>; University of Messina, Dept. of Clinical and Experimental Medicine, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Orlando+A%22">Orlando A</searchLink>; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Conforti+FS%22">Conforti FS</searchLink>; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Bezzio+C%22">Bezzio C</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy.<br /><searchLink fieldCode="AU" term="%22Castiglione+F%22">Castiglione F</searchLink>; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Fantini+MC%22">Fantini MC</searchLink>; University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Savarino+EV%22">Savarino EV</searchLink>; University of Padua, Department of Surgery- Oncology and Gastroenterology, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Festa+S%22">Festa S</searchLink>; 'San Filippo Neri' Hospital, IBD Unit, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Ribaldone+DG%22">Ribaldone DG</searchLink>; University of Turin, Department of Medical Sciences, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Mocci+G%22">Mocci G</searchLink>; Azienda Ospedaliera ARNAS G. Brotzu, SC Gastroenterologia, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Grossi+L%22">Grossi L</searchLink>; 'G d'Annunzio' University, Gastroenterology Unit- 'Spirito Santo' Hospital, Pescara, Italy.<br /><searchLink fieldCode="AU" term="%22Viganò+C%22">Viganò C</searchLink>; Division of Gastroenterology- Center for Autoimmune Liver Diseases- Department of Medicine and Surgery- University of Milano-Bicocca; European Reference Network on Hepatological Diseases ERN RARE-LIVER- Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Imperatore+N%22">Imperatore N</searchLink>; Gastroenterology and Endoscopy Unit, Santa Maria delle Grazie Hospital, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Ceccarelli+L%22">Ceccarelli L</searchLink>; Azienda Ospedaliero Universitaria Pisana, Gastroenterology Unit, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Gabrielli+AMC%22">Gabrielli AMC</searchLink>; ASST Fatebenefratelli-Sacco- Milano, Gastroenterology and Endoscopy Unit, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Scardino+G%22">Scardino G</searchLink>; 'Valduce' Hospital, Gastroenterology Department, Como, Italy.<br /><searchLink fieldCode="AU" term="%22Saibeni+S%22">Saibeni S</searchLink>; IBD Centre, Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho, Italy.<br /><searchLink fieldCode="AU" term="%22Balestrieri+P%22">Balestrieri P</searchLink>; Gastroenterology Unit, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Principi+M%22">Principi M</searchLink>; University of Bari, Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J- Gastroenterology Unit, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Campigotto+M%22">Campigotto M</searchLink>; ASUGI- Ospedale di Cattinara, Gastroenterologia ed Endoscopia Digestiva, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Gravina+AG%22">Gravina AG</searchLink>; University of Campania Luigi Vanvitelli, Department of Precision Medicine- Hepatogastroenterology Unit, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Spagnuolo+R%22">Spagnuolo R</searchLink>; Dipartimento di Scienze della Salute Università 〈Magna Graecia〉 Catanzaro.<br /><searchLink fieldCode="AU" term="%22Scaldaferri+F%22">Scaldaferri F</searchLink>; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS- IBD Unit- CEMAD- Digestive Diseases Center- Medicina Interna e Gastroenterologia, Roma, Italy; Dipartimento di medicina e chirurgia Traslazionale - Università cattolica del Sacro Cuore- Roma, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Neri+B%22">Neri B</searchLink>; University 'Tor Vergata' of Rome, Department of Systems Medicine, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Sario+AD%22">Sario AD</searchLink>; Unità di Gastroenterologia ed Endoscopia Digestiva, Ospedale di Senigallia, AST Ancona.<br /><searchLink fieldCode="AU" term="%22Baldoni+M%22">Baldoni M</searchLink>; SC Gastroenterologia ed Endoscopia Digestiva AO-Universitaria di Perugia Dipartimento di Medicina e Chirurgia.<br /><searchLink fieldCode="AU" term="%22Mitri+RD%22">Mitri RD</searchLink>; Gastroenterology and Endoscopy Unit, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Tettoni+E%22">Tettoni E</searchLink>; Gastroenterology and Digestive Endoscopy Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Calderone+S%22">Calderone S</searchLink>; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Armuzzi+A%22">Armuzzi A</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy.<br /><searchLink fieldCode="AU" term="%22Macaluso+FS%22">Macaluso FS</searchLink>; 'Villa Sofia-Cervello' Hospital, Inflammatory bowel disease Unit, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Vecchi+M%22">Vecchi M</searchLink>; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Ventimiglia+M%22">Ventimiglia M</searchLink>; Italian Ministry of Health, Directorate General of Medical Device and Pharmaceutical Service, Roma, Italy; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Caprioli+F%22">Caprioli F</searchLink>; University of Milan, Department of Pathophysiology and Transplantation, Milano, Italy; Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Gastroenterology and Endoscopy Unit, Milano, Italy. Electronic address: flavio.caprioli@unimi.it.
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