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Oncogene aberrations drive medulloblastoma progression, not initiation.

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Title: Oncogene aberrations drive medulloblastoma progression, not initiation.
Authors: Okonechnikov K; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Joshi P; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Körber V; Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rademacher A; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany., Bortolomeazzi M; Single-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mallm JP; Single-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany., Vaillant J; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., da Silva PBG; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Statz B; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Sepp M; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Sarropoulos I; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Yamada T; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Wittmann A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schramm K; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fiesel P; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; CCU Neuropathology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Jones B; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany., Jäger N; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Milde T; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Pajtler KW; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany., van Tilburg CM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Witt O; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Bochennek K; Frankfurt University Hospital, Goethe University, Frankfurt, Germany., Weber KJ; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT) Frankfurt, Frankfurt am Main, Germany., Nonnenmacher L; University Children's Hospital, Ulm, Germany., Reimann C; University Children's Hospital, Ulm, Germany., Ghasemi DR; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jones DTW; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Korshunov A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; CCU Neuropathology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Rippe K; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany., Westermann F; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Thongjuea S; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Höfer T; Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaessmann H; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kutscher LM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de., Pfister SM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de.
Source: Nature [Nature] 2025 Jun; Vol. 642 (8069), pp. 1062-1072. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncogene aberrations drive medulloblastoma progression, not initiation.
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Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pajtler+KW%22">Pajtler KW</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22van+Tilburg+CM%22">van Tilburg CM</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bochennek+K%22">Bochennek K</searchLink>; Frankfurt University Hospital, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+KJ%22">Weber KJ</searchLink>; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Frankfurt am Main, Germany.; 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Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Korshunov+A%22">Korshunov A</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; CCU Neuropathology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rippe+K%22">Rippe K</searchLink>; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Westermann+F%22">Westermann F</searchLink>; 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Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de.
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      – TitleFull: Oncogene aberrations drive medulloblastoma progression, not initiation.
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      – PersonEntity:
          Name:
            NameFull: Witt O
      – PersonEntity:
          Name:
            NameFull: Bochennek K
      – PersonEntity:
          Name:
            NameFull: Weber KJ
      – PersonEntity:
          Name:
            NameFull: Nonnenmacher L
      – PersonEntity:
          Name:
            NameFull: Reimann C
      – PersonEntity:
          Name:
            NameFull: Ghasemi DR
      – PersonEntity:
          Name:
            NameFull: Schüller U
      – PersonEntity:
          Name:
            NameFull: Mynarek M
      – PersonEntity:
          Name:
            NameFull: Rutkowski S
      – PersonEntity:
          Name:
            NameFull: Jones DTW
      – PersonEntity:
          Name:
            NameFull: Korshunov A
      – PersonEntity:
          Name:
            NameFull: Rippe K
      – PersonEntity:
          Name:
            NameFull: Westermann F
      – PersonEntity:
          Name:
            NameFull: Thongjuea S
      – PersonEntity:
          Name:
            NameFull: Höfer T
      – PersonEntity:
          Name:
            NameFull: Kaessmann H
      – PersonEntity:
          Name:
            NameFull: Kutscher LM
      – PersonEntity:
          Name:
            NameFull: Pfister SM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2025 Jun
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 642
            – Type: issue
              Value: 8069
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1