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Predicting adenine base editing efficiencies in different cellular contexts by deep learning.

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Title: Predicting adenine base editing efficiencies in different cellular contexts by deep learning.
Authors: Kissling L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mollaysa A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Janjuha S; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mathis N; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Marquart KF; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Weber Y; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Moon WJ; Acuitas Therapeutics Inc., Vancouver, BC, Canada., Lin PJC; Acuitas Therapeutics Inc., Vancouver, BC, Canada., Fan SHY; Acuitas Therapeutics Inc., Vancouver, BC, Canada., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Vadovics M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Allam A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tam YK; Acuitas Therapeutics Inc., Vancouver, BC, Canada., Krauthammer M; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. michael.krauthammer@uzh.ch., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch.
Source: Genome biology [Genome Biol] 2025 May 08; Vol. 26 (1), pp. 115. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kissling+L%22">Kissling L</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mollaysa+A%22">Mollaysa A</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Janjuha+S%22">Janjuha S</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mathis+N%22">Mathis N</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Marquart+KF%22">Marquart KF</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Weber+Y%22">Weber Y</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moon+WJ%22">Moon WJ</searchLink>; Acuitas Therapeutics Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+PJC%22">Lin PJC</searchLink>; Acuitas Therapeutics Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Fan+SHY%22">Fan SHY</searchLink>; Acuitas Therapeutics Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Muramatsu+H%22">Muramatsu H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vadovics+M%22">Vadovics M</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Allam+A%22">Allam A</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tam+YK%22">Tam YK</searchLink>; Acuitas Therapeutics Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Krauthammer+M%22">Krauthammer M</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. michael.krauthammer@uzh.ch.<br /><searchLink fieldCode="AU" term="%22Schwank+G%22">Schwank G</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch.
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  Data: <searchLink fieldCode="JN" term="%22100960660%22">Genome biology</searchLink> [Genome Biol] 2025 May 08; Vol. 26 (1), pp. 115. <i>Date of Electronic Publication: </i>2025 May 08.
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