Impaired T cell and neoantigen retention in time-serial analysis of metastatic non-small cell lung cancer in patients unresponsive to TIL cell therapy.

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Title: Impaired T cell and neoantigen retention in time-serial analysis of metastatic non-small cell lung cancer in patients unresponsive to TIL cell therapy.
Authors: Wang C; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. chao.wang@moffitt.org., Yu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Teer JK; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Yao J; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Du D; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Liu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Thompson ZJ; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Wang MH; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Welsh EA; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Memon D; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Chan TA; Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Makarov V; Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Saeed L; Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Boyle TA; Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Fang B; Proteomics & Metabolomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Koomen JM; Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Cox C; Immune and Cellular Therapy Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Landin AM; Immune and Cellular Therapy Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Yoder SJ; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Kim S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Radiation Oncology, Immunology, Cancer Biology, Mayo Clinic Alix College of Medicine & Health Sciences, Jacksonville, FL, USA., Chen DT; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Pilon-Thomas SA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Antonia SJ; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Haura EB; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Creelan BC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. ben.creelan@moffitt.org.; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. ben.creelan@moffitt.org.
Source: Nature cancer [Nat Cancer] 2025 May; Vol. 6 (5), pp. 801-819. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-1347
DOI:10.1038/s43018-025-00946-x