Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception.

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Title: Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception.
Authors: Zhu B; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen P; Institute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Aminu M; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li JR; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Fujimoto J; Clinical Research Center in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan., Tian Y; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hong L; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen H; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li C; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vokes N; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moreira AL; Department of Pathology, NYU Langone Health, New York, NY, USA., Gibbons DL; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Solis Soto LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Parra Cuentas ER; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Shi O; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Diao S; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ye J; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rojas FR; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vilar E; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Department of Translational Molecular Pathology and Sheikn Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen K; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Navin N; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nilsson M; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Huang B; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heeke S; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Haymaker CL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Velcheti V; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA., Sterman DH; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA; Cardiothoracic Surgery, NYU Grossman School of Medicine, New York, NY, USA., Kochat V; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Padron WI; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Alexandrov LB; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Wei Z; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Le X; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fukuoka J; Department of Pathology Informatics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Lee JJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pass HI; Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA., Davis M; Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA., Hanash S; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, CA, USA., Cheng C; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Dubinett S; Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Spira A; Pathology & Laboratory Medicine, and Bioinformatics, Boston University, Boston, MA, USA., Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lippman SM; UC San Diego School of Medicine, La Jolla, CA, USA., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Reuben A; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu J; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jzhang20@mdanderson.org.
Source: Cancer cell [Cancer Cell] 2025 Jun 09; Vol. 43 (6), pp. 1125-1140.e10. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-3686
DOI:10.1016/j.ccell.2025.04.003