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Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.

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Title: Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.
Authors: Khan Y; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania., Davis CN; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Jinwala Z; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Feuer KL; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania., Toikumo S; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Hartwell EE; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, California; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Genomic Medicine, University of California San Diego, La Jolla, California., Peterson RE; Institute for Department of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York., Hatoum AS; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri., Kranzler HR; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Kember RL; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania. Electronic address: rkember@pennmedicine.upenn.edu.
Source: Biological psychiatry [Biol Psychiatry] 2026 Jan 01; Vol. 99 (1), pp. 68-79. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
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  Data: Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.
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  Data: <searchLink fieldCode="AU" term="%22Khan+Y%22">Khan Y</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Davis+CN%22">Davis CN</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Jinwala+Z%22">Jinwala Z</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Feuer+KL%22">Feuer KL</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Toikumo+S%22">Toikumo S</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hartwell+EE%22">Hartwell EE</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Sanchez-Roige+S%22">Sanchez-Roige S</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, California; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Genomic Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Peterson+RE%22">Peterson RE</searchLink>; Institute for Department of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.<br /><searchLink fieldCode="AU" term="%22Hatoum+AS%22">Hatoum AS</searchLink>; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Kranzler+HR%22">Kranzler HR</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kember+RL%22">Kember RL</searchLink>; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania. Electronic address: rkember@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%220213264%22">Biological psychiatry</searchLink> [Biol Psychiatry] 2026 Jan 01; Vol. 99 (1), pp. 68-79. <i>Date of Electronic Publication: </i>2025 May 08.
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