View in EDS HTML Full Text PDF Full Text

Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.

Saved in:
Bibliographic Details
Title: Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.
Authors: Metcalf KJ; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Wo G; IT, Merck & Co. Inc, Rahway, NJ, USA., Zaragoza JP; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Raoufi F; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Baker J; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Chen D; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Derebe M; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Hogan J; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Hsu A; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Kofman E; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Leigh D; IT, Merck & Co. Inc, Rahway, NJ, USA., Li M; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Malashock D; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Mann C; IT, Merck & Co. Inc, Rahway, NJ, USA., Motlagh S; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Park J; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Sathiyamoorthy K; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Shidhore M; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Tang Y; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Teng K; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Williams K; IT, Merck & Co. Inc, Rahway, NJ, USA., Waight A; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Yilmaz S; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Zhang F; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Zhong H; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Fayadat-Dilman L; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA., Bailly M; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.
Source: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2502127. Date of Electronic Publication: 2025 May 10.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40347482
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Metcalf+KJ%22">Metcalf KJ</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wo+G%22">Wo G</searchLink>; IT, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zaragoza+JP%22">Zaragoza JP</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Raoufi+F%22">Raoufi F</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Baker+J%22">Baker J</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Derebe+M%22">Derebe M</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hogan+J%22">Hogan J</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+A%22">Hsu A</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kofman+E%22">Kofman E</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Leigh+D%22">Leigh D</searchLink>; IT, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Malashock+D%22">Malashock D</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mann+C%22">Mann C</searchLink>; IT, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Motlagh+S%22">Motlagh S</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Sathiyamoorthy+K%22">Sathiyamoorthy K</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Shidhore+M%22">Shidhore M</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Teng+K%22">Teng K</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Williams+K%22">Williams K</searchLink>; IT, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Waight+A%22">Waight A</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Yilmaz+S%22">Yilmaz S</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Fayadat-Dilman+L%22">Fayadat-Dilman L</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Bailly+M%22">Bailly M</searchLink>; Discovery Biologics, Merck & Co. Inc, Rahway, NJ, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101479829%22">MAbs</searchLink> [MAbs] 2025 Dec; Vol. 17 (1), pp. 2502127. <i>Date of Electronic Publication: </i>2025 May 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101479829 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1942-0870 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219420862%22">19420862 </searchLink><i>NLM ISO Abbreviation: </i>MAbs <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40347482
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/19420862.2025.2502127
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2502127
    Titles:
      – TitleFull: Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Metcalf KJ
      – PersonEntity:
          Name:
            NameFull: Wo G
      – PersonEntity:
          Name:
            NameFull: Zaragoza JP
      – PersonEntity:
          Name:
            NameFull: Raoufi F
      – PersonEntity:
          Name:
            NameFull: Baker J
      – PersonEntity:
          Name:
            NameFull: Chen D
      – PersonEntity:
          Name:
            NameFull: Derebe M
      – PersonEntity:
          Name:
            NameFull: Hogan J
      – PersonEntity:
          Name:
            NameFull: Hsu A
      – PersonEntity:
          Name:
            NameFull: Kofman E
      – PersonEntity:
          Name:
            NameFull: Leigh D
      – PersonEntity:
          Name:
            NameFull: Li M
      – PersonEntity:
          Name:
            NameFull: Malashock D
      – PersonEntity:
          Name:
            NameFull: Mann C
      – PersonEntity:
          Name:
            NameFull: Motlagh S
      – PersonEntity:
          Name:
            NameFull: Park J
      – PersonEntity:
          Name:
            NameFull: Sathiyamoorthy K
      – PersonEntity:
          Name:
            NameFull: Shidhore M
      – PersonEntity:
          Name:
            NameFull: Tang Y
      – PersonEntity:
          Name:
            NameFull: Teng K
      – PersonEntity:
          Name:
            NameFull: Williams K
      – PersonEntity:
          Name:
            NameFull: Waight A
      – PersonEntity:
          Name:
            NameFull: Yilmaz S
      – PersonEntity:
          Name:
            NameFull: Zhang F
      – PersonEntity:
          Name:
            NameFull: Zhong H
      – PersonEntity:
          Name:
            NameFull: Fayadat-Dilman L
      – PersonEntity:
          Name:
            NameFull: Bailly M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1942-0870
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: MAbs
              Type: main
ResultId 1