Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality.
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| Title: | Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality. |
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| Authors: | Cunningham CE; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vizeacoumar FS; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Zhang Y; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Kyrylenko L; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Both S; Department of Pharmacy, Pharmaceutical Biology, Saarland University, PharmaScienceHub, 66123 Saarbrücken, Germany., Maranda V; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dong H; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Price JDW; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Gao P; Global Institute for Food Security, University of Saskatchewan, Saskatoon, SK S7N 4L8, Canada; Agriculture and Agri-Food Canada, Saskatoon Research and Development Centre, 107 Science Place, Saskatoon, SK S7N 0X2, Canada., Wagner K; Antiviral & Antivirulence Drugs (AVID), Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Wu Y; Antiviral & Antivirulence Drugs (AVID), Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Lazell-Wright M; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Ganapathysamy A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Hari R; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Bhanumathy KK; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Denomy C; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Saxena A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vizeacoumar JP; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Morales AM; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Khan F; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Mosley S; Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada., Chen A; Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada., Katrii T; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Zoller BGE; Antiviral & Antivirulence Drugs (AVID), Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Rajamanickam K; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Walke P; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, and Cameco MS Neuroscience Research Centre, 701 Queen St., Saskatoon, SK S7K 0M7, Canada., Gong L; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Patel H; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Elhasasna H; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dahiya R; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Abuhussein O; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dmitriev A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Freywald T; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Munhoz EP; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Ruppin E; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Bioinformatics and Computational Biology and Department of Computer Sciences, University of Maryland, College Park, MD 20742, USA., Lee JS; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Bioinformatics and Computational Biology and Department of Computer Sciences, University of Maryland, College Park, MD 20742, USA; Department of Precision Medicine, School of Medicine and Department of Artificial Intelligence, Sungkyunkwan University, Suwon 16419, Republic of Korea., Rox K; Department of Chemical Biology (CBIO), Helmholtz Center for Infection Research (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany., Koebel M; Department of Pathology, University of Calgary, Calgary, AB, Canada., Hopkins L; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Lee CH; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada., Yadav S; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Gasparoni G; Department of Genetics, Saarland University, Saarbrücken, Germany., Walter J; Department of Genetics, Saarland University, Saarbrücken, Germany., Krishnan A; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, and Cameco MS Neuroscience Research Centre, 701 Queen St., Saskatoon, SK S7K 0M7, Canada., Datla R; Global Institute for Food Security, University of Saskatchewan, Saskatoon, SK S7N 4L8, Canada., Toosi B; Western College of Veterinary Medicine, University of Saskatchewan, Room 2343, 52 Campus Drive, Saskatoon S7N 5B4, Canada., Baker K; Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada., Meens J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Cescon DW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ailles L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Leary SC; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Wu Y; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Empting M; Antiviral & Antivirulence Drugs (AVID), Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address: martin.empting@helmholtz-hips.de., Kiemer AK; Department of Pharmacy, Pharmaceutical Biology, Saarland University, PharmaScienceHub, 66123 Saarbrücken, Germany; Center for Gender-Specific Biology and Medicine (CGBM), 66421 Homburg, Germany. Electronic address: pharm.bio.kiemer@uni-saarland.de., Freywald A; Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada. Electronic address: andrew.freywald@usask.ca., Vizeacoumar FJ; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada. Electronic address: franco.vizeacoumar@usask.ca. |
| Source: | Cell genomics [Cell Genom] 2025 Jun 11; Vol. 5 (6), pp. 100876. Date of Electronic Publication: 2025 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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