RNA transcripts serve as a template for double-strand break repair in human cells.

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Title: RNA transcripts serve as a template for double-strand break repair in human cells.
Authors: Jalan M; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Brambati A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shah H; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medicine, Cornell University, New York, NY, USA., McDermott N; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Patel J; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhu Y; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Doymaz A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medicine, Cornell University, New York, NY, USA., Wu J; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; SUNY Downstate Health Sciences University, New York, NY, USA., Anderson KS; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gazzo A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pareja F; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yamaguchi TN; Department of Human Genetics, University of California, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, CA, USA., Vougiouklakis T; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ahmed-Seghir S; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Steinberg P; Department of Human Genetics, University of California, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, USA., Neiman-Golden A; Department of Human Genetics, University of California, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, USA., Azeroglu B; Laboratory of Genome Integrity, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA., Gomez-Aguilar J; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., da Silva EM; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hussain S; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Higginson D; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boutros PC; Department of Human Genetics, University of California, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, CA, USA.; Broad Stem Cell Research Center, University of California, Los Angeles, CA, USA., Riaz N; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reis-Filho JS; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; AstraZeneca, Gaithersburg, MD, USA., Powell SN; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. powells@mskcc.org.; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. powells@mskcc.org., Sfeir A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. sfeira@mskcc.org.
Source: Nature communications [Nat Commun] 2025 May 10; Vol. 16 (1), pp. 4349. Date of Electronic Publication: 2025 May 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59510-x