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Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial.

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Title: Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial.
Authors: Garrison SR; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Bakal JA; Provincial Research Data Services, Alberta Health Services, Edmonton, Canada.; Alberta Strategy for Patient Oriented Research Support Unit (AbSPORU), Edmonton, Canada., Kolber MR; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Korownyk CS; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Green LA; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Kirkwood JEM; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., McAlister FA; Alberta Strategy for Patient Oriented Research Support Unit (AbSPORU), Edmonton, Canada.; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada., Padwal RS; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada., Lewanczuk R; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada., Hill MD; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Singer AG; Department of Medicine, University of Manitoba, Winnipeg, Canada., Katz A; Department of Medicine, University of Manitoba, Winnipeg, Canada., Kelmer MD; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Gayayan A; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Campbell FN; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Vucenovic A; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Archibald NR; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Yeung JMS; Provincial Research Data Services, Alberta Health Services, Edmonton, Canada., Youngson ERE; Provincial Research Data Services, Alberta Health Services, Edmonton, Canada.; Alberta Strategy for Patient Oriented Research Support Unit (AbSPORU), Edmonton, Canada., McGrail K; School of Population and Public Health, University of British Columbia, Vancouver, Canada.; Centre for Health Services and Policy Research, Vancouver, British Columbia, Canada., O'Neill BG; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Greiver M; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Manca DP; Department of Family Medicine, University of Alberta, Edmonton, Canada., Kraut RY; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada., Wang T; Provincial Research Data Services, Alberta Health Services, Edmonton, Canada., Manns BJ; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Mangin DA; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Primary Care, University of Otago, Christchurch, New Zealand., MacLean C; Academic Family Medicine, University of Saskatchewan, Saskatoon, Canada., McCormack J; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada., Wong ST; School of Population and Public Health, University of British Columbia, Vancouver, Canada.; School of Nursing, University of British Columbia, Vancouver, Canada., Norris C; Faculty of Nursing, University of Alberta, Edmonton, Canada., Allan GM; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada.
Source: JAMA [JAMA] 2025 Jun 17; Vol. 333 (23), pp. 2061-2072.
Publication Type: Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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  Data: Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial.
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Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Kirkwood+JEM%22">Kirkwood JEM</searchLink>; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22McAlister+FA%22">McAlister FA</searchLink>; Alberta Strategy for Patient Oriented Research Support Unit (AbSPORU), Edmonton, Canada.; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Padwal+RS%22">Padwal RS</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Lewanczuk+R%22">Lewanczuk R</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Hill+MD%22">Hill MD</searchLink>; 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School of Population and Public Health, University of British Columbia, Vancouver, Canada.; Centre for Health Services and Policy Research, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22O'Neill+BG%22">O'Neill BG</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Greiver+M%22">Greiver M</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Manca+DP%22">Manca DP</searchLink>; Department of Family Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Kraut+RY%22">Kraut RY</searchLink>; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Provincial Research Data Services, Alberta Health Services, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Manns+BJ%22">Manns BJ</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Mangin+DA%22">Mangin DA</searchLink>; Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Primary Care, University of Otago, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22MacLean+C%22">MacLean C</searchLink>; Academic Family Medicine, University of Saskatchewan, Saskatoon, Canada.<br /><searchLink fieldCode="AU" term="%22McCormack+J%22">McCormack J</searchLink>; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+ST%22">Wong ST</searchLink>; School of Population and Public Health, University of British Columbia, Vancouver, Canada.; School of Nursing, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Norris+C%22">Norris C</searchLink>; Faculty of Nursing, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Allan+GM%22">Allan GM</searchLink>; Pragmatic Trials Collaborative, University of Alberta, Edmonton, Canada.; Department of Family Medicine, University of Alberta, Edmonton, Canada.
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  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2025 Jun 17; Vol. 333 (23), pp. 2061-2072.
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        Value: 10.1001/jama.2025.4390
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