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Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis.

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Title: Shear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosis.
Authors: Chen YC; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia., Louis NELR; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia., Huang A; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Sun A; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia., Dupuy A; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia., Moldovan L; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia., Pelaia T; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia., Ren J; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia., Cohen TS; Vaccines and Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD., Gilbert SC; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Tran H; Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia., Peter K; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, Australia., McFadyen JD; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Ju LA; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia.
Source: Blood [Blood] 2025 Jul 24; Vol. 146 (4), pp. 496-503.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Louis+NELR%22">Louis NELR</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+A%22">Huang A</searchLink>; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sun+A%22">Sun A</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dupuy+A%22">Dupuy A</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Moldovan+L%22">Moldovan L</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pelaia+T%22">Pelaia T</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cohen+TS%22">Cohen TS</searchLink>; Vaccines and Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD.<br /><searchLink fieldCode="AU" term="%22Gilbert+SC%22">Gilbert SC</searchLink>; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tran+H%22">Tran H</searchLink>; Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Peter+K%22">Peter K</searchLink>; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22McFadyen+JD%22">McFadyen JD</searchLink>; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ju+LA%22">Ju LA</searchLink>; School of Biomedical Engineering, The University of Sydney, Darlington, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Heart Research Institute, Newtown, NSW, Australia.; The University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW, Australia.
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              Text: 2025 Jul 24
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