Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.
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| Title: | Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs. |
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| Authors: | Thoms JAI; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia. j.thoms@unsw.edu.au., Yan F; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Hampton HR; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Davidson S; ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, ACT, Australia.; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Joshi S; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Saw J; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia., Sarowar CH; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Lim XY; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Nunez AC; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Kakadia PM; Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Bhuyan GS; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Zou X; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Nguyen M; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Ghodousi ES; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Koch FC; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Vafaee F; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.; UNSW Data Science Hub, University of New South Wales, Sydney, NSW, Australia., Thompson IR; Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Karimi MM; Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Pickford R; Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, Australia., Raftery MJ; Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, Australia., Hough S; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Buckland G; ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, ACT, Australia.; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Bailey M; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Ghodke Y; ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, ACT, Australia.; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Absar N; Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Vaughan L; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Westmead Hospital, Sydney, NSW, Australia.; ICPMR, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia., Pasalic L; Westmead Hospital, Sydney, NSW, Australia.; ICPMR, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia., Fong CY; Department of Haematology, Austin Health, Melbourne, VIC, Australia., Kenealy M; Cabrini Hospital, Melbourne, VIC, Australia., Hiwase DK; Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia., Stoddart RI; University of New South Wales, Sydney, NSW, Australia., Mohammed S; ICPMR, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia., Lee L; Royal North Shore Hospital, Sydney, NSW, Australia., Passam FH; Haematology Research Group, Heart Research Institute, Sydney, NSW, Australia.; Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Larsen SR; Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Spring KJ; Medical Oncology Group, Liverpool Clinical School, School of Medicine, Western Sydney University and Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia.; South-West Sydney Clinical Campuses, UNSW Medicine & Health, Sydney, NSW, Australia., Skarratt KK; Sydney Medical School, Nepean Clinical School, Faculty of Medicine and Health, University of Sydney, Nepean Hospital, Kingswood, NSW, Australia., Rebeiro P; Blacktown Hospital, Sydney, NSW, Australia., Presgrave P; Wollongong Hospital, Wollongong, NSW, Australia., Stevenson WS; Royal North Shore Hospital, Sydney, NSW, Australia., Ling S; Liverpool Hospital, Sydney, NSW, Australia., Tiley C; Central Coast Health, Gosford Hospital, Gosford, NSW, Australia., Fuller SJ; Sydney Medical School, Nepean Clinical School, Faculty of Medicine and Health, University of Sydney, Nepean Hospital, Kingswood, NSW, Australia., Roncolato F; St. George Hospital, Sydney, NSW, Australia., Enjeti AK; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.; University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Program, Hunter Cancer Research Institute, New Lambton Heights, NSW, Australia., Hoenemann D; Otway Pharmaceutical Development and Consulting Pty Ltd, Forrest, VIC, Australia., Lemech C; Scientia Clinical Research, Medical Oncology, Prince of Wales Hospital, Sydney, NSW, Australia., Jolly CJ; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Bohlander SK; Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Curtis DJ; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia., Wong JWH; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China., Unnikrishnan A; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Hertzberg M; Department of Clinical Haematology, Prince of Wales Hospital, Sydney, NSW, Australia., Olivier J; School of Mathematics and Statistics, University of New South Wales, Sydney, NSW, Australia., Polizzotto MN; ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, ACT, Australia. mark.polizzotto@anu.edu.au.; Kirby Institute, University of New South Wales, Sydney, NSW, Australia. mark.polizzotto@anu.edu.au., Pimanda JE; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; Department of Clinical Haematology, Prince of Wales Hospital, Sydney, NSW, Australia. jpimanda@unsw.edu.au. |
| Source: | Nature communications [Nat Commun] 2025 May 13; Vol. 16 (1), pp. 4451. Date of Electronic Publication: 2025 May 13. |
| Publication Type: | Journal Article; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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