Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione.
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| Title: | Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione. |
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| Authors: | Yang K; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA., Beaudoin JJ; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA., Howell BA; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA., Mullin J; Physiologically-Based Pharmacokinetics Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA., Amini E; Physiologically-Based Pharmacokinetics Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA., Lai JCK; Kenvue, Summit, New Jersey, USA., Gelotte CK; Independent Consultant, Westbrook, Connecticut, USA., Sista S; Kenvue, Summit, New Jersey, USA., Atillasoy E; Kenvue, Summit, New Jersey, USA. |
| Source: | CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Jul; Vol. 14 (7), pp. 1236-1251. Date of Electronic Publication: 2025 May 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| FullText | Links: – Type: pdflink Text: Availability: 1 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40365931 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Beaudoin+JJ%22">Beaudoin JJ</searchLink>; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Howell+BA%22">Howell BA</searchLink>; Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Mullin+J%22">Mullin J</searchLink>; Physiologically-Based Pharmacokinetics Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Amini+E%22">Amini E</searchLink>; Physiologically-Based Pharmacokinetics Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lai+JCK%22">Lai JCK</searchLink>; Kenvue, Summit, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Gelotte+CK%22">Gelotte CK</searchLink>; Independent Consultant, Westbrook, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Sista+S%22">Sista S</searchLink>; Kenvue, Summit, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Atillasoy+E%22">Atillasoy E</searchLink>; Kenvue, Summit, New Jersey, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101580011%22">CPT: pharmacometrics & systems pharmacology</searchLink> [CPT Pharmacometrics Syst Pharmacol] 2025 Jul; Vol. 14 (7), pp. 1236-1251. <i>Date of Electronic Publication: </i>2025 May 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101580011 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2163-8306 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221638306%22">21638306 </searchLink><i>NLM ISO Abbreviation: </i>CPT Pharmacometrics Syst Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40365931 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/psp4.70045 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1236 Titles: – TitleFull: Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yang K – PersonEntity: Name: NameFull: Beaudoin JJ – PersonEntity: Name: NameFull: Howell BA – PersonEntity: Name: NameFull: Mullin J – PersonEntity: Name: NameFull: Amini E – PersonEntity: Name: NameFull: Lai JCK – PersonEntity: Name: NameFull: Gelotte CK – PersonEntity: Name: NameFull: Sista S – PersonEntity: Name: NameFull: Atillasoy E IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2025 Jul Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2163-8306 Numbering: – Type: volume Value: 14 – Type: issue Value: 7 Titles: – TitleFull: CPT: pharmacometrics & systems pharmacology Type: main |
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