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Structural basis of human Nav1.5 gating mechanisms.

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Title: Structural basis of human Nav1.5 gating mechanisms.
Authors: Biswas R; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210., López-Serrano AL; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Purohit A; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210., Ramirez-Navarro A; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Huang HL; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210., Grandinetti G; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Center for Electron Microscopy and Analysis, College of Engineering, The Ohio State University, Columbus, OH 43210., Cheng X; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.; Translational Data Analytics Institute at The Ohio State University, Columbus, OH 43210., Heissler SM; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210., Deschênes I; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Chinthalapudi K; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 May 20; Vol. 122 (20), pp. e2416181122. Date of Electronic Publication: 2025 May 14.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Structural basis of human Na<subscript>v</subscript>1.5 gating mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Biswas+R%22">Biswas R</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22López-Serrano+AL%22">López-Serrano AL</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Purohit+A%22">Purohit A</searchLink>; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Ramirez-Navarro+A%22">Ramirez-Navarro A</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Huang+HL%22">Huang HL</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Grandinetti+G%22">Grandinetti G</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Center for Electron Microscopy and Analysis, College of Engineering, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.; Translational Data Analytics Institute at The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Heissler+SM%22">Heissler SM</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Deschênes+I%22">Deschênes I</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Chinthalapudi+K%22">Chinthalapudi K</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 May 20; Vol. 122 (20), pp. e2416181122. <i>Date of Electronic Publication: </i>2025 May 14.
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              Text: 2025 May 20
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