Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization.

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Title: Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization.
Authors: Pea A; Department of General and Pancreatic Surgery-The Pancreas Institute, Verona University Hospital Trust, Verona, Italy., Bevere M; ARC-Net Research Center, University of Verona, Verona, Italy., Gkountakos A; ARC-Net Research Center, University of Verona, Verona, Italy., Pasini D; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.; Department of Medicine, University of Verona, Verona, Italy., Fiorini D; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Mafficini A; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Golovco S; ARC-Net Research Center, University of Verona, Verona, Italy., Simbolo M; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Pedron S; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Sciammarella C; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Mattiolo P; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Mombello A; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Villanova M; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Franzina C; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Masetto F; ARC-Net Research Center, University of Verona, Verona, Italy., Ciulla C; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Sperandio N; ARC-Net Research Center, University of Verona, Verona, Italy., Fujikura K; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Ahadi MS; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, and Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia., Samra JS; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Johns AL; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia., Verheij J; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Stommel MWJ; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., van Santvoort H; Department of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht and St Antonius Hospital, Utrecht, Netherlands., Schubert Santana L; Wolfson Wohl Cancer Research Centre, Research Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Malleo G; Department of General and Pancreatic Surgery-The Pancreas Institute, Verona University Hospital Trust, Verona, Italy., Milella M; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Brosens LAA; Department of Pathology, UMC Utrecht, Utrecht University, Utrecht, and Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Wood LD; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Chang DK; Wolfson Wohl Cancer Research Centre, Research Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK., De Robertis R; Department of Diagnostics and Public Health, Section of Radiology, University of Verona, Verona, Italy., D'Onofrio M; Department of Diagnostics and Public Health, Section of Radiology, University of Verona, Verona, Italy., Gill AJ; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, and Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia., Salvia R; Department of General and Pancreatic Surgery-The Pancreas Institute, Verona University Hospital Trust, Verona, Italy., Corbo V; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Lawlor RT; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Scarpa A; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Luchini C; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
Source: The Journal of pathology [J Pathol] 2025 Aug; Vol. 266 (4-5), pp. 421-434. Date of Electronic Publication: 2025 May 15.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization.
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Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Golovco+S%22">Golovco S</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Simbolo+M%22">Simbolo M</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Pedron+S%22">Pedron S</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Sciammarella+C%22">Sciammarella C</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Mattiolo+P%22">Mattiolo P</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Mombello+A%22">Mombello A</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Villanova+M%22">Villanova M</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Franzina+C%22">Franzina C</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Masetto+F%22">Masetto F</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Ciulla+C%22">Ciulla C</searchLink>; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Sperandio+N%22">Sperandio N</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Fujikura+K%22">Fujikura K</searchLink>; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ahadi+MS%22">Ahadi MS</searchLink>; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, and Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Samra+JS%22">Samra JS</searchLink>; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Johns+AL%22">Johns AL</searchLink>; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Verheij+J%22">Verheij J</searchLink>; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Stommel+MWJ%22">Stommel MWJ</searchLink>; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Santvoort+H%22">van Santvoort H</searchLink>; Department of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht and St Antonius Hospital, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schubert+Santana+L%22">Schubert Santana L</searchLink>; Wolfson Wohl Cancer Research Centre, Research Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Malleo+G%22">Malleo G</searchLink>; Department of General and Pancreatic Surgery-The Pancreas Institute, Verona University Hospital Trust, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Milella+M%22">Milella M</searchLink>; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Brosens+LAA%22">Brosens LAA</searchLink>; Department of Pathology, UMC Utrecht, Utrecht University, Utrecht, and Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wood+LD%22">Wood LD</searchLink>; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chang+DK%22">Chang DK</searchLink>; Wolfson Wohl Cancer Research Centre, Research Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22De+Robertis+R%22">De Robertis R</searchLink>; Department of Diagnostics and Public Health, Section of Radiology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22D'Onofrio+M%22">D'Onofrio M</searchLink>; Department of Diagnostics and Public Health, Section of Radiology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Gill+AJ%22">Gill AJ</searchLink>; Royal North Shore Hospital, St Leonards, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, and Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Salvia+R%22">Salvia R</searchLink>; Department of General and Pancreatic Surgery-The Pancreas Institute, Verona University Hospital Trust, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Corbo+V%22">Corbo V</searchLink>; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Lawlor+RT%22">Lawlor RT</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Scarpa+A%22">Scarpa A</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Luchini+C%22">Luchini C</searchLink>; ARC-Net Research Center, University of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
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