Precise targeting of HIV broadly neutralizing antibody precursors in humans.
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| Title: | Precise targeting of HIV broadly neutralizing antibody precursors in humans. |
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| Authors: | Caniels TG; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Prabhakaran M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., MacPhee KJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Wu W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., van der Straten K; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Agrawal S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Derking R; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Reiss EIMM; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Millard K; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Desrosiers A; Vaccine Research Unit, The George Washington University, Washington, DC, USA., Bethony J; Vaccine Research Unit, The George Washington University, Washington, DC, USA., Malkin E; Vaccine Research Unit, The George Washington University, Washington, DC, USA., Liesdek MH; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., van der Veen A; Department of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Klouwens M; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands.; Department of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Snitselaar JL; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Bouhuijs JH; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Bronson R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Jean-Baptiste J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Gajjala S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Rikhtegaran Tehrani Z; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Benner A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ramaswami M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Duff MO; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Liu YW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Sato AH; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kim JY; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Baken IJL; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Mendes Silva C; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Bijl TPL; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., van Rijswijk J; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Burger JA; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Cupo A; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Yasmeen A; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Phulera S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Randall KN Jr; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Zhang S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Corcoran MM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Regadas I; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Sullivan AC; Foundation for the National Institutes of Health, Inc., Bethesda, MD, USA., Brown DM; Foundation for the National Institutes of Health, Inc., Bethesda, MD, USA., Bohl JA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Greene KM; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Gao H; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Yates NL; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Sawant S; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Prins JM; Department of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Kootstra NA; Department of Experimental Immunology, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Kaminsky SM; Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA., Barin B; The Emmes Company, Rockville, MD, USA., Rahaman F; International AIDS Vaccine Initiative (IAVI), New York, NY, USA., Meller M; International AIDS Vaccine Initiative (IAVI), New York, NY, USA., Philiponis V; International AIDS Vaccine Initiative (IAVI), New York, NY, USA., Laufer DS; International AIDS Vaccine Initiative (IAVI), New York, NY, USA., Lombardo A; International AIDS Vaccine Initiative (IAVI), New York, NY, USA., Mwoga L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Shotorbani S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Holman D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Tomaras GD; Department of Surgery, Duke University Medical Center, Durham, NC, USA., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands., Montefiori DC; Foundation for the National Institutes of Health, Inc., Bethesda, MD, USA., McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Hyrien O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Moore JP; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Diemert DJ; Vaccine Research Unit, The George Washington University, Washington, DC, USA., de Bree GJ; Department of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands., Andrews SF; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. |
| Source: | Science (New York, N.Y.) [Science] 2025 Jul 31; Vol. 389 (6759), pp. eadv5572. Date of Electronic Publication: 2025 Jul 31. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adv5572 |
