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Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site.

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Title: Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site.
Authors: Dakin LA; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Xing L; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Hall J; Medicine Design, Pfizer Inc, Groton, CT, USA., Ding W; Medicine Design, Pfizer Inc, Groton, CT, USA., Vajdos FF; Medicine Design, Pfizer Inc, Groton, CT, USA., Pelker JW; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Ramsey S; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Balbo P; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Sahasrabudhe PV; Medicine Design, Pfizer Inc, Groton, CT, USA., Banker ME; Medicine Design, Pfizer Inc, Groton, CT, USA., Choi WY; Medicine Design, Pfizer Inc, Groton, CT, USA., Wright SW; Medicine Design, Pfizer Inc, Groton, CT, USA., Chang JS; Medicine Design, Pfizer Inc, Groton, CT, USA., Curto JM; Medicine Design, Pfizer Inc, Groton, CT, USA., Davoren JE; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Drozda SE; Medicine Design, Pfizer Inc, Groton, CT, USA., Fennell KF; Medicine Design, Pfizer Inc, Groton, CT, USA., Futatsugi K; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Kortum S; Medicine Design, Pfizer Inc, Groton, CT, USA., Lee KL; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Liu S; Medicine Design, Pfizer Inc, Groton, CT, USA., Lovering F; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Nicki JA; Medicine Design, Pfizer Inc, Groton, CT, USA., Trujillo JI; Medicine Design, Pfizer Inc, Groton, CT, USA., Vincent F; Medicine Design, Pfizer Inc, Groton, CT, USA., Schnute ME; Medicine Design, Pfizer Inc, Cambridge, MA, USA. mark.e.schnute@pfizer.com.
Source: Nature communications [Nat Commun] 2025 May 16; Vol. 16 (1), pp. 4579. Date of Electronic Publication: 2025 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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