Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site.
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| Title: | Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. |
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| Authors: | Dakin LA; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Xing L; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Hall J; Medicine Design, Pfizer Inc, Groton, CT, USA., Ding W; Medicine Design, Pfizer Inc, Groton, CT, USA., Vajdos FF; Medicine Design, Pfizer Inc, Groton, CT, USA., Pelker JW; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Ramsey S; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Balbo P; Inflammation and Immunology Research, Pfizer Inc, Cambridge, MA, USA., Sahasrabudhe PV; Medicine Design, Pfizer Inc, Groton, CT, USA., Banker ME; Medicine Design, Pfizer Inc, Groton, CT, USA., Choi WY; Medicine Design, Pfizer Inc, Groton, CT, USA., Wright SW; Medicine Design, Pfizer Inc, Groton, CT, USA., Chang JS; Medicine Design, Pfizer Inc, Groton, CT, USA., Curto JM; Medicine Design, Pfizer Inc, Groton, CT, USA., Davoren JE; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Drozda SE; Medicine Design, Pfizer Inc, Groton, CT, USA., Fennell KF; Medicine Design, Pfizer Inc, Groton, CT, USA., Futatsugi K; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Kortum S; Medicine Design, Pfizer Inc, Groton, CT, USA., Lee KL; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Liu S; Medicine Design, Pfizer Inc, Groton, CT, USA., Lovering F; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Nicki JA; Medicine Design, Pfizer Inc, Groton, CT, USA., Trujillo JI; Medicine Design, Pfizer Inc, Groton, CT, USA., Vincent F; Medicine Design, Pfizer Inc, Groton, CT, USA., Schnute ME; Medicine Design, Pfizer Inc, Cambridge, MA, USA. mark.e.schnute@pfizer.com. |
| Source: | Nature communications [Nat Commun] 2025 May 16; Vol. 16 (1), pp. 4579. Date of Electronic Publication: 2025 May 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59919-4 |
