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siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.

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Title: siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.
Authors: Colazo JM; Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA., Keech MC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Shah V; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lo JH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cassidy NT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., McCune JT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., DeJulius CR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cho H; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gibson-Corley KN; Department of Pathology, Microbiology, and Immunology, Division of Comparative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hasty KA; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA., Crofford LJ; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Cook RS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. craig.duvall@vanderbilt.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Aug; Vol. 9 (8), pp. 1366-1383. Date of Electronic Publication: 2025 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.
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  Data: <searchLink fieldCode="AU" term="%22Colazo+JM%22">Colazo JM</searchLink>; Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Keech+MC%22">Keech MC</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shah+V%22">Shah V</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hoogenboezem+EN%22">Hoogenboezem EN</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lo+JH%22">Lo JH</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Francini+N%22">Francini N</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cassidy+NT%22">Cassidy NT</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sorets+AG%22">Sorets AG</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22McCune+JT%22">McCune JT</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22DeJulius+CR%22">DeJulius CR</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cho+H%22">Cho H</searchLink>; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Michell+DL%22">Michell DL</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Maerz+T%22">Maerz T</searchLink>; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Vickers+KC%22">Vickers KC</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gibson-Corley+KN%22">Gibson-Corley KN</searchLink>; Department of Pathology, Microbiology, and Immunology, Division of Comparative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hasty+KA%22">Hasty KA</searchLink>; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Crofford+LJ%22">Crofford LJ</searchLink>; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cook+RS%22">Cook RS</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Duvall+CL%22">Duvall CL</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. craig.duvall@vanderbilt.edu.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Aug; Vol. 9 (8), pp. 1366-1383. <i>Date of Electronic Publication: </i>2025 May 16.
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