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APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.

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Title: APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.
Authors: Thomassen JQ; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Hampton L; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Ulms B; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Grenier-Boley B; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland., Garcia P; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain., Castillo-Morales A; UK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK., Kikuchi M; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan., Gim J; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea.; Gwangju Alzheimer's & Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, 61452, Republic of Korea., Cao H; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China., Küçükali F; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Amin N; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Yoon D; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea., de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Jerez PA; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Alvarez V; Laboratorio de Genética. Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Bellenguez C; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Bergh S; The Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.; Norwegian National Centre for Aging and Health, Vestfold Health Trust, Tønsberg, Norway., Billingsley K; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Blauwendraat C; Coalition for Aligning Science, 5425 Wisconsin Ave #600, Chevy Chase, MD 20815, USA., Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Borroni B; Department of Clinical and Experimental Sciences, University of Brescia, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Bossù P; Laboratory of Experimental Neuropsychobiology, Clinical Neuroscience and Neurorehabilitation Department, IRCCS Santa Lucia Foundation, Rome, Italy., Bullido MJ; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC).; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain., Daniele A; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy., Carracedo Á; Grupo de Medicina Xenómica, CIBERER, CIMUS. Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica- IDIS, Santiago de Compostela, Spain., de Mendonça A; Faculty of Medicine, University of Lisbon, Portugal., Cookson M; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dols-Icardo O; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Dufouil C; University of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Escott-Price V; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Fladby T; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.; Department of Neurology, Akershus University Hospital, Lørenskog, Norway., Fratiglioni L; Karolinska University Hospital, Theme inflammation and Aging, Sweden.; Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of ARC, Stockholm, Sweden., Fu AKY; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, 518057, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, 518055, China., Galimberti D; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., García-Alberca JM; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Giedraitis V; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid., Graff C; Karolinska University Hospital, Theme inflammation and Aging, Sweden.; Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of ARC, Stockholm, Sweden., Grimmer T; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland., Hanon O; Université Paris Cité, EA 4468, APHP, Hospital Broca, Memory Resource and Research Centre of de Paris-Broca-Ile de France, Paris, France., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Germany., Heilmann-Hemibach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Hort J; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic., Jessen F; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Jensen K; Center for Noninvasive Diagnostics, TGen, Phoenix, AZ, USA., Jonson C; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Kim Y; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea., Kuznetsov N; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Leinonen V; Department of Neurosurgery, Kuopio University Hospital, Puijonlaaksontie 2 FI-70210 Kuopio, Finland.; Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland., Lipponen A; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland., Luo J; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen., Makarious M; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Martiskainen H; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mecocci P; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Italy.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Mir P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Seville, Spain., Miyashita A; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Mok KY; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, U.K., Porcel LM; Neurological Tissue Bank - Biobanc- Hospital Clinic -IDIBAPS, Barcelona, Spain.; Alzheimer's disease and other cognitive disorders Unit. Neurology Department, Hospital Clinic, Barcelona, Spain., Moreno F; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology. Hospital Universitario Donostia. San Sebastian, Spain.; Neurosciences Area. Instituto Biodonostia. San Sebastian, Spain., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Pastor P; Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Pérez-Tur J; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203 Berlin, Germany., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Popp J; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.; Institute for Regenerative Medicine, University of Zürich, Switzerland., Rainero I; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga. Málaga, Spain., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany., Rodriguez-Rodriguez E; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Rongve A; Haugesund Hospital, Department of Research and Innovation, Haugesund, Norway., Rossi G; Unit of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Royo JL; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga. Málaga, Spain., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria.; Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany., Saltvedt I; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Sánchez-Valle R; Alzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain., Sandau N; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Scarmeas N; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Greece., Scheffler K; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Neurology and Clinical Neurophysiology, Trondheim University Hospital, Trondheim, Norway., Scherbaum N; Department of Psychiatry and Psychotherapy, LVR-Klinikum Essen, University of Duisburg-Essen, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Selbæk G; Norwegian National Advisory Unit on Aging and Health, Vestfold Health Trust, Tønsberg, Norway.; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.; Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway., Seripa D; Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari 'A. Moro, Bari, Italy.; Academic Division 'C. Frugoni' & Hospital Division of Internal and Geriatric Medicine, Policlinico Hospital, Bari, Italy., Spallazzi M; Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Stordal E; Namsos Hospital, Namsos, Norway., Tesi N; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., Tremolizzo L; Neurology Unit, IRCCS 'San Gerardo dei Tintori', Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Tripathi KP; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Estudios en Neurociencias y Sistemas Complejos (ENyS) CONICET-HEC-UNAJ., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Williams J; UK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK.; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Medical Science Department, iBiMED, Aveiro, Portugal., Aarsland D; Department of Old Age Psychiatry, Division of Academic Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Wolfson Centre for Age Related Diseases, Division of Neuroscience of the Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Stavanger University Hospital, Stavanger, Norway., Singleton AB; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Amouyel P; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Debette S; University of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France., Nicolas G; Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, Rouen, France., van der Lee S; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Holstege H; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; VIB Center for Brain and Disease Research, ON5 Herestraat 49 - box 602, 3000 Leuven, Belgium.; Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., Fernandez MV; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain., Kehoe PG; Bristol Medical School, University of Bristol, Bristol, UK., Sleegers K; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Ingelsson M; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Andreassen OA; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway., Holmans PA; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK., Sánchez-Juan P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain., Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK., Ip NY; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, 518057, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, 518055, China., Lee KH; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea.; Gwangju Alzheimer's & Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, 61452, Republic of Korea.; Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, 41062, Repuiblic of Korea., Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland., Lambert JC; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., van Duijn C; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands., Nalls M; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 May 09. Date of Electronic Publication: 2025 May 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.
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  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Thomassen+JQ%22">Thomassen JQ</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hampton+L%22">Hampton L</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ulms+B%22">Ulms B</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Grenier-Boley+B%22">Grenier-Boley B</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Heikkinen+S%22">Heikkinen S</searchLink>; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Garcia+P%22">Garcia P</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castillo-Morales+A%22">Castillo-Morales A</searchLink>; UK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Kikuchi+M%22">Kikuchi M</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan.<br /><searchLink fieldCode="AU" term="%22Gim+J%22">Gim J</searchLink>; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea.; Gwangju Alzheimer's & Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, 61452, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cao+H%22">Cao H</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Küçükali+F%22">Küçükali F</searchLink>; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Amin+N%22">Amin N</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Yoon+D%22">Yoon D</searchLink>; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22de+Rojas+I%22">de Rojas I</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Jerez+PA%22">Jerez PA</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+V%22">Alvarez V</searchLink>; Laboratorio de Genética. Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA).<br /><searchLink fieldCode="AU" term="%22Arosio+B%22">Arosio B</searchLink>; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bellenguez+C%22">Bellenguez C</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Bergh+S%22">Bergh S</searchLink>; The Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.; Norwegian National Centre for Aging and Health, Vestfold Health Trust, Tønsberg, Norway.<br /><searchLink fieldCode="AU" term="%22Billingsley+K%22">Billingsley K</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Coalition for Aligning Science, 5425 Wisconsin Ave #600, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Borroni+B%22">Borroni B</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bossù+P%22">Bossù P</searchLink>; Laboratory of Experimental Neuropsychobiology, Clinical Neuroscience and Neurorehabilitation Department, IRCCS Santa Lucia Foundation, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bullido+MJ%22">Bullido MJ</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC).; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Daniele+A%22">Daniele A</searchLink>; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carracedo+Á%22">Carracedo Á</searchLink>; Grupo de Medicina Xenómica, CIBERER, CIMUS. Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica- IDIS, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22de+Mendonça+A%22">de Mendonça A</searchLink>; Faculty of Medicine, University of Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Cookson+M%22">Cookson M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Deckert+J%22">Deckert J</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dichgans+M%22">Dichgans M</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Djurovic+S%22">Djurovic S</searchLink>; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Dols-Icardo+O%22">Dols-Icardo O</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dufouil+C%22">Dufouil C</searchLink>; University of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Düzel+E%22">Düzel E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Escott-Price+V%22">Escott-Price V</searchLink>; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Fladby+T%22">Fladby T</searchLink>; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.<br /><searchLink fieldCode="AU" term="%22Fratiglioni+L%22">Fratiglioni L</searchLink>; Karolinska University Hospital, Theme inflammation and Aging, Sweden.; Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of ARC, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Fu+AKY%22">Fu AKY</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, 518057, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, 518055, China.<br /><searchLink fieldCode="AU" term="%22Galimberti+D%22">Galimberti D</searchLink>; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22García-Alberca+JM%22">García-Alberca JM</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Giedraitis+V%22">Giedraitis V</searchLink>; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Garcia-Ribas+G%22">Garcia-Ribas G</searchLink>; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid.<br /><searchLink fieldCode="AU" term="%22Graff+C%22">Graff C</searchLink>; Karolinska University Hospital, Theme inflammation and Aging, Sweden.; Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of ARC, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Grimmer+T%22">Grimmer T</searchLink>; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Grünblatt+E%22">Grünblatt E</searchLink>; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hanon+O%22">Hanon O</searchLink>; Université Paris Cité, EA 4468, APHP, Hospital Broca, Memory Resource and Research Centre of de Paris-Broca-Ile de France, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hausner+L%22">Hausner L</searchLink>; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heilmann-Hemibach+S%22">Heilmann-Hemibach S</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hort+J%22">Hort J</searchLink>; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Jessen+F%22">Jessen F</searchLink>; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Jensen+K%22">Jensen K</searchLink>; Center for Noninvasive Diagnostics, TGen, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Jonson+C%22">Jonson C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Well-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kuznetsov+N%22">Kuznetsov N</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Leinonen+V%22">Leinonen V</searchLink>; Department of Neurosurgery, Kuopio University Hospital, Puijonlaaksontie 2 FI-70210 Kuopio, Finland.; Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Lipponen+A%22">Lipponen A</searchLink>; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen.<br /><searchLink fieldCode="AU" term="%22Makarious+M%22">Makarious M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Martiskainen+H%22">Martiskainen H</searchLink>; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Masullo+C%22">Masullo C</searchLink>; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mecocci+P%22">Mecocci P</searchLink>; Division of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Italy.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Mehrabian+S%22">Mehrabian S</searchLink>; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Mir+P%22">Mir P</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Miyashita+A%22">Miyashita A</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan.<br /><searchLink fieldCode="AU" term="%22Moebus+S%22">Moebus S</searchLink>; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Mok+KY%22">Mok KY</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, U.K.<br /><searchLink fieldCode="AU" term="%22Porcel+LM%22">Porcel LM</searchLink>; Neurological Tissue Bank - Biobanc- Hospital Clinic -IDIBAPS, Barcelona, Spain.; Alzheimer's disease and other cognitive disorders Unit. Neurology Department, Hospital Clinic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno+F%22">Moreno F</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology. Hospital Universitario Donostia. San Sebastian, Spain.; Neurosciences Area. Instituto Biodonostia. San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Nacmias+B%22">Nacmias B</searchLink>; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Parnetti+L%22">Parnetti L</searchLink>; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Pastor+P%22">Pastor P</searchLink>; Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Tur+J%22">Pérez-Tur J</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+YAL%22">Pijnenburg YAL</searchLink>; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Piñol-Ripoll+G%22">Piñol-Ripoll G</searchLink>; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Popp+J%22">Popp J</searchLink>; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.; Institute for Regenerative Medicine, University of Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rainero+I%22">Rainero I</searchLink>; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Real+LM%22">Real LM</searchLink>; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga. Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Riedel-Heller+S%22">Riedel-Heller S</searchLink>; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Rodriguez+E%22">Rodriguez-Rodriguez E</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Rongve+A%22">Rongve A</searchLink>; Haugesund Hospital, Department of Research and Innovation, Haugesund, Norway.<br /><searchLink fieldCode="AU" term="%22Rossi+G%22">Rossi G</searchLink>; Unit of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Royo+JL%22">Royo JL</searchLink>; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga. Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Rujescu+D%22">Rujescu D</searchLink>; Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria.; Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Saltvedt+I%22">Saltvedt I</searchLink>; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Sáez+ME%22">Sáez ME</searchLink>; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Valle+R%22">Sánchez-Valle R</searchLink>; Alzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanchez-Garcia+F%22">Sanchez-Garcia F</searchLink>; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.<br /><searchLink fieldCode="AU" term="%22Sandau+N%22">Sandau N</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Scarmeas+N%22">Scarmeas N</searchLink>; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Greece.<br /><searchLink fieldCode="AU" term="%22Scheffler+K%22">Scheffler K</searchLink>; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Neurology and Clinical Neurophysiology, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Scherbaum+N%22">Scherbaum N</searchLink>; Department of Psychiatry and Psychotherapy, LVR-Klinikum Essen, University of Duisburg-Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Selbæk+G%22">Selbæk G</searchLink>; Norwegian National Advisory Unit on Aging and Health, Vestfold Health Trust, Tønsberg, Norway.; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.; Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway.<br /><searchLink fieldCode="AU" term="%22Seripa+D%22">Seripa D</searchLink>; Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Solfrizzi+V%22">Solfrizzi V</searchLink>; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari 'A. Moro, Bari, Italy.; Academic Division 'C. Frugoni' & Hospital Division of Internal and Geriatric Medicine, Policlinico Hospital, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Spallazzi+M%22">Spallazzi M</searchLink>; Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Squassina+A%22">Squassina A</searchLink>; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Stordal+E%22">Stordal E</searchLink>; Namsos Hospital, Namsos, Norway.<br /><searchLink fieldCode="AU" term="%22Tesi+N%22">Tesi N</searchLink>; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tremolizzo+L%22">Tremolizzo L</searchLink>; Neurology Unit, IRCCS 'San Gerardo dei Tintori', Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Tripathi+KP%22">Tripathi KP</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Estudios en Neurociencias y Sistemas Complejos (ENyS) CONICET-HEC-UNAJ.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Williams+J%22">Williams J</searchLink>; UK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK.; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Medical Science Department, iBiMED, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Aarsland+D%22">Aarsland D</searchLink>; Department of Old Age Psychiatry, Division of Academic Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Wolfson Centre for Age Related Diseases, Division of Neuroscience of the Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Stavanger University Hospital, Stavanger, Norway.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Amouyel+P%22">Amouyel P</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Debette+S%22">Debette S</searchLink>; University of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Nicolas+G%22">Nicolas G</searchLink>; Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, Rouen, France.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+S%22">van der Lee S</searchLink>; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Holstege+H%22">Holstege H</searchLink>; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; VIB Center for Brain and Disease Research, ON5 Herestraat 49 - box 602, 3000 Leuven, Belgium.; Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Fernandez+MV%22">Fernandez MV</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kehoe+PG%22">Kehoe PG</searchLink>; Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Sleegers+K%22">Sleegers K</searchLink>; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Ingelsson+M%22">Ingelsson M</searchLink>; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ghidoni+R%22">Ghidoni R</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Holmans+PA%22">Holmans PA</searchLink>; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Sánchez-Juan+P%22">Sánchez-Juan P</searchLink>; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sims+R%22">Sims R</searchLink>; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Ip+NY%22">Ip NY</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, 518057, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, 518055, China.<br /><searchLink fieldCode="AU" term="%22Lee+KH%22">Lee KH</searchLink>; Department of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.; BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, 61452, Republic of Korea.; Gwangju Alzheimer's & Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, 61452, Republic of Korea.; Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, 41062, Repuiblic of Korea.<br /><searchLink fieldCode="AU" term="%22Ikeuchi+T%22">Ikeuchi T</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Japan.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hiltunen+M%22">Hiltunen M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Lambert+JC%22">Lambert JC</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22van+Duijn+C%22">van Duijn C</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nalls+M%22">Nalls M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Frikke-Schmidt+R%22">Frikke-Schmidt R</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark.
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 May 09. <i>Date of Electronic Publication: </i>2025 May 09.
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  Data: Journal Article; Preprint
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
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      – Type: doi
        Value: 10.1101/2025.05.07.25327065
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        Text: English
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      – TitleFull: APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.
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          Name:
            NameFull: Sleegers K
      – PersonEntity:
          Name:
            NameFull: Ingelsson M
      – PersonEntity:
          Name:
            NameFull: Ghidoni R
      – PersonEntity:
          Name:
            NameFull: Andreassen OA
      – PersonEntity:
          Name:
            NameFull: Holmans PA
      – PersonEntity:
          Name:
            NameFull: Sánchez-Juan P
      – PersonEntity:
          Name:
            NameFull: Sims R
      – PersonEntity:
          Name:
            NameFull: Ip NY
      – PersonEntity:
          Name:
            NameFull: Lee KH
      – PersonEntity:
          Name:
            NameFull: Ikeuchi T
      – PersonEntity:
          Name:
            NameFull: Ramirez A
      – PersonEntity:
          Name:
            NameFull: Ruiz A
      – PersonEntity:
          Name:
            NameFull: Hiltunen M
      – PersonEntity:
          Name:
            NameFull: Lambert JC
      – PersonEntity:
          Name:
            NameFull: van Duijn C
      – PersonEntity:
          Name:
            NameFull: Nalls M
      – PersonEntity:
          Name:
            NameFull: Frikke-Schmidt R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 05
              Text: 2025 May 09
              Type: published
              Y: 2025
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1