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Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.

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Title: Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Authors: Walsh TS; Usher Institute, University of Edinburgh, Edinburgh, Scotland., Parker RA; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Aitken LM; City St George's University of London, London, England., McKenzie CA; National Institute for Health and Care Research, Biomedical Research Centre, Southampton, England.; Perioperative and Critical Care Theme, University of Southampton, Southampton, England., Emerson L; City St George's University of London, London, England., Boyd J; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Macdonald A; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Beveridge G; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Giddings A; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Hope D; Edinburgh Critical Care Research Group, NHS Lothian, Edinburgh, Scotland., Irvine S; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Tuck S; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Lone NI; Usher Institute, University of Edinburgh, Edinburgh, Scotland., Kydonaki K; Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece.; School of Health and Social Care, Edinburgh Napier University, Edinburgh, Scotland., Norrie J; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Brealey D; Division of Critical Care, University College London Hospitals, London, England.; NIHR UCLH Biomedical Research Centre, London, England., Antcliffe D; Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College Hospitals, London, England., Reay M; Russells Hall Hospital, Dudley, England., Williams A; St Georges NHS Trust, London, England., Bewley J; Bristol Royal Infirmary, Bristol, England., Creagh-Brown B; Royal Surrey NHS Foundation Trust and the School of Medicine, University of Surrey, Surrey, England., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland., Dark P; Critical Care Medicine, Division of Immunology and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, England., Wise MP; Department of Adult Critical Care, University Hospital of Wales, Cardiff., Gordon AC; Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, London, England., Perkins GD; Warwick Medical School, University of Warwick, Coventry, England., Reade MC; Medical School, University of Queensland, Brisbane, Australia., Blackwood B; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland., MacLullich A; Ageing and Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Glen R; Critical Care Patient and Public Involvement Group, NHS Lothian, Edinburgh, Scotland., Page VJ; Intensive Care, West Hertfordshire Hospitals NHS Trust, Watford, England., Weir CJ; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Corporate Authors: A2B Trial Investigators
Source: JAMA [JAMA] 2025 Jul 01; Vol. 334 (1), pp. 32-45.
Publication Type: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Pragmatic Clinical Trial; Research Support, Non-U.S. Gov't; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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