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Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment.

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Title: Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment.
Authors: Aviles-Huerta D; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Del Pizzo R; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Kowar A; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Baig AH; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Palazzo G; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Stepanova E; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Amaya Ramirez CC; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., D'Agostino S; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Ratto E; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Pechincha C; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Siefert N; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Engel H; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Du S; Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Cadenas-De Miguel S; Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium., Miao B; Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Cruz-Vilchez VM; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Müller-Decker K; Core Facility Tumor Models, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Elia I; Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium., Sun C; Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Palm W; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany., Loayza-Puch F; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany. f.loayza-puch@dkfz-heidelberg.de.
Source: Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4652. Date of Electronic Publication: 2025 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59986-7