A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial.
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| Title: | A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. |
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| Authors: | van Lemmen MA; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands., van Velzen M; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands., Sarton EY; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, the Netherlands., Dahan A; MediD Consultancy Group, Amsterdam, the Netherlands. adahan@MediDConsultancy.com.; Outcomes Research Consortium, Houston, TX, USA. adahan@MediDConsultancy.com.; Centre for Human Drug Research, Leiden, the Netherlands. adahan@MediDConsultancy.com.; Painless Foundation, Leiden, the Netherlands. adahan@MediDConsultancy.com., Niesters M; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.; Centre for Human Drug Research, Leiden, the Netherlands.; Painless Foundation, Leiden, the Netherlands., van der Schrier RM; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands. r.m.van_der_schrier@lumc.nl. |
| Source: | Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4659. Date of Electronic Publication: 2025 May 19. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Comparative Study; Equivalence Trial |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40389500 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22van+Lemmen+MA%22">van Lemmen MA</searchLink>; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Velzen+M%22">van Velzen M</searchLink>; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sarton+EY%22">Sarton EY</searchLink>; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dahan+A%22">Dahan A</searchLink>; MediD Consultancy Group, Amsterdam, the Netherlands. adahan@MediDConsultancy.com.; Outcomes Research Consortium, Houston, TX, USA. adahan@MediDConsultancy.com.; Centre for Human Drug Research, Leiden, the Netherlands. adahan@MediDConsultancy.com.; Painless Foundation, Leiden, the Netherlands. adahan@MediDConsultancy.com.<br /><searchLink fieldCode="AU" term="%22Niesters+M%22">Niesters M</searchLink>; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.; Centre for Human Drug Research, Leiden, the Netherlands.; Painless Foundation, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Schrier+RM%22">van der Schrier RM</searchLink>; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands. r.m.van&#95;der&#95;schrier@lumc.nl. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4659. <i>Date of Electronic Publication: </i>2025 May 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Comparative Study; Equivalence Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40389500 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-59932-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 4659 Titles: – TitleFull: A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: van Lemmen MA – PersonEntity: Name: NameFull: van Velzen M – PersonEntity: Name: NameFull: Sarton EY – PersonEntity: Name: NameFull: Dahan A – PersonEntity: Name: NameFull: Niesters M – PersonEntity: Name: NameFull: van der Schrier RM IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 05 Text: 2025 May 19 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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