A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial.
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| Title: | A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. |
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| Authors: | van Lemmen MA; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands., van Velzen M; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands., Sarton EY; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, the Netherlands., Dahan A; MediD Consultancy Group, Amsterdam, the Netherlands. adahan@MediDConsultancy.com.; Outcomes Research Consortium, Houston, TX, USA. adahan@MediDConsultancy.com.; Centre for Human Drug Research, Leiden, the Netherlands. adahan@MediDConsultancy.com.; Painless Foundation, Leiden, the Netherlands. adahan@MediDConsultancy.com., Niesters M; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.; Centre for Human Drug Research, Leiden, the Netherlands.; Painless Foundation, Leiden, the Netherlands., van der Schrier RM; Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands. r.m.van_der_schrier@lumc.nl. |
| Source: | Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4659. Date of Electronic Publication: 2025 May 19. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Comparative Study; Equivalence Trial |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59932-7 |
