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The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound.

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Title: The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound.
Authors: Belda H; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal., Bradley D; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université Laval, Québec, Quebec, Canada.; Institut de Biologie Intégrative et des Systems, Université Laval, Québec, Quebec, Canada.; PROTEO, Le Groupement Québécois de Recherche sur la Function, l'Ingénierie et les Applications des Proteins, Université Laval, Québec, Quebec, Canada., Christodoulou E; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK., Nofal SD; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal., Broncel M; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK., Jones D; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK., Davies H; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK., Bertran MT; Protein-Protein Interaction Laboratory, The Francis Crick Institute, London, UK., Purkiss AG; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK., Ogrodowicz RW; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK., Joshi D; Chemical Biology Science Technology Platform, The Francis Crick Institute, London, UK., O'Reilly N; Chemical Biology Science Technology Platform, The Francis Crick Institute, London, UK., Walport L; Protein-Protein Interaction Laboratory, The Francis Crick Institute, London, UK., Powell A; CrickGSK Biomedical LinkLabs, GSK, Stevenage, UK., House D; CrickGSK Biomedical LinkLabs, GSK, Stevenage, UK., Kjaer S; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK., Claessens A; LPHI, MIVEGEC, INSERM, CNRS, IRD, University of Montpellier, Montpellier, France., Landry CR; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université Laval, Québec, Quebec, Canada.; Institut de Biologie Intégrative et des Systems, Université Laval, Québec, Quebec, Canada.; PROTEO, Le Groupement Québécois de Recherche sur la Function, l'Ingénierie et les Applications des Proteins, Université Laval, Québec, Quebec, Canada., Treeck M; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK. moritz.treeck@gimm.pt.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. moritz.treeck@gimm.pt.
Source: Nature microbiology [Nat Microbiol] 2025 Jun; Vol. 10 (6), pp. 1463-1483. Date of Electronic Publication: 2025 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Belda+H%22">Belda H</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Bradley+D%22">Bradley D</searchLink>; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université Laval, Québec, Quebec, Canada.; Institut de Biologie Intégrative et des Systems, Université Laval, Québec, Quebec, Canada.; PROTEO, Le Groupement Québécois de Recherche sur la Function, l'Ingénierie et les Applications des Proteins, Université Laval, Québec, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Christodoulou+E%22">Christodoulou E</searchLink>; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Nofal+SD%22">Nofal SD</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Broncel+M%22">Broncel M</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Jones+D%22">Jones D</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Davies+H%22">Davies H</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Bertran+MT%22">Bertran MT</searchLink>; Protein-Protein Interaction Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Purkiss+AG%22">Purkiss AG</searchLink>; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Ogrodowicz+RW%22">Ogrodowicz RW</searchLink>; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Joshi+D%22">Joshi D</searchLink>; Chemical Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Reilly+N%22">O'Reilly N</searchLink>; Chemical Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Walport+L%22">Walport L</searchLink>; Protein-Protein Interaction Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Powell+A%22">Powell A</searchLink>; CrickGSK Biomedical LinkLabs, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22House+D%22">House D</searchLink>; CrickGSK Biomedical LinkLabs, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Kjaer+S%22">Kjaer S</searchLink>; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Claessens+A%22">Claessens A</searchLink>; LPHI, MIVEGEC, INSERM, CNRS, IRD, University of Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Landry+CR%22">Landry CR</searchLink>; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université Laval, Québec, Quebec, Canada.; Institut de Biologie Intégrative et des Systems, Université Laval, Québec, Quebec, Canada.; PROTEO, Le Groupement Québécois de Recherche sur la Function, l'Ingénierie et les Applications des Proteins, Université Laval, Québec, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Treeck+M%22">Treeck M</searchLink>; Signalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, UK. moritz.treeck@gimm.pt.; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. moritz.treeck@gimm.pt.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2025 Jun; Vol. 10 (6), pp. 1463-1483. <i>Date of Electronic Publication: </i>2025 May 19.
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