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Fenofibrate treatment during lactation prevents liver and adipose tissue associated metabolic dysfunction in a rat model of childhood obesity.

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Title: Fenofibrate treatment during lactation prevents liver and adipose tissue associated metabolic dysfunction in a rat model of childhood obesity.
Authors: Saavedra LPJ; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil. Electronic address: saavedralpj@gmail.com., Raposo SR; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Assakawa ALM; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Lucredi NC; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Peres MNC; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Piovan S; Department of Biochemistry, State University of West Paraná, Cascavel, PR, Brazil., Gonçalves GD; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Moreira VM; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Barbosa LF; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil., Sousa D; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra. Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine. Ph.D. Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal., Farias Dos Santos FC; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Amaro A; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra. Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine. Ph.D. Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal., Ferreira-Junior MD; State University of Campinas, Brazil., Graceli JB; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil; Animal Science, School of Agricultural Sciences, Southern Illinois University, Carbondale, IL, USA., Matafome P; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal., Comar JF; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Gomes RM; Laboratory of Endocrine Physiology and MetabolismDepartment of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil; Department of Structural and Functional Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Jiménez-Chillarón JC; Institut de Recerca Sant Joan de Déu (IRSJD), Endocrinology, Esplugues, Spain; Universitat de Barcelona-Facultat Medicina-Bellvitge, L'Hospitalet, Spain., Almeida DL; Department of Biochemistry, State University of West Paraná, Cascavel, PR, Brazil., Mathias PCF; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil. Electronic address: pmathias@uem.br.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Jul; Vol. 188, pp. 118166. Date of Electronic Publication: 2025 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: Fenofibrate treatment during lactation prevents liver and adipose tissue associated metabolic dysfunction in a rat model of childhood obesity.
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  Data: <searchLink fieldCode="AU" term="%22Saavedra+LPJ%22">Saavedra LPJ</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil. Electronic address: saavedralpj@gmail.com.<br /><searchLink fieldCode="AU" term="%22Raposo+SR%22">Raposo SR</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Assakawa+ALM%22">Assakawa ALM</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Lucredi+NC%22">Lucredi NC</searchLink>; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Peres+MNC%22">Peres MNC</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Piovan+S%22">Piovan S</searchLink>; Department of Biochemistry, State University of West Paraná, Cascavel, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+GD%22">Gonçalves GD</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Moreira+VM%22">Moreira VM</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+LF%22">Barbosa LF</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+D%22">Sousa D</searchLink>; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra. Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine. Ph.D. Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal.<br /><searchLink fieldCode="AU" term="%22Farias+Dos+Santos+FC%22">Farias Dos Santos FC</searchLink>; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil.<br /><searchLink fieldCode="AU" term="%22Amaro+A%22">Amaro A</searchLink>; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra. Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine. Ph.D. Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal.<br /><searchLink fieldCode="AU" term="%22Ferreira-Junior+MD%22">Ferreira-Junior MD</searchLink>; State University of Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Graceli+JB%22">Graceli JB</searchLink>; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil; Animal Science, School of Agricultural Sciences, Southern Illinois University, Carbondale, IL, USA.<br /><searchLink fieldCode="AU" term="%22Matafome+P%22">Matafome P</searchLink>; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal Clinical Academic Center of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Comar+JF%22">Comar JF</searchLink>; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Gomes+RM%22">Gomes RM</searchLink>; Laboratory of Endocrine Physiology and MetabolismDepartment of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil; Department of Structural and Functional Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Jiménez-Chillarón+JC%22">Jiménez-Chillarón JC</searchLink>; Institut de Recerca Sant Joan de Déu (IRSJD), Endocrinology, Esplugues, Spain; Universitat de Barcelona-Facultat Medicina-Bellvitge, L'Hospitalet, Spain.<br /><searchLink fieldCode="AU" term="%22Almeida+DL%22">Almeida DL</searchLink>; Department of Biochemistry, State University of West Paraná, Cascavel, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Mathias+PCF%22">Mathias PCF</searchLink>; Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, PR, Brazil. Electronic address: pmathias@uem.br.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Jul; Vol. 188, pp. 118166. <i>Date of Electronic Publication: </i>2025 May 19.
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