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Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary.

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Title: Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary.
Authors: Rebello RJ; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Posner A; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Dong R; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Prall OWJ; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Sivakumaran T; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Mitchell CB; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Flynn A; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Caneborg A; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Mitchell C; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Kanwal S; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Fedele C; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Webb S; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Fisher K; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Wong HL; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Balachander S; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Zhu W; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Nicolson S; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Dimitriadis V; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Wilcken N; The Westmead Institute for Medical Research, Sydney, NSW, Australia., DeFazio A; The Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, NSW, Australia., Gao B; Department of Medical Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia., Singh M; Department of Medical Oncology, Barwon Health Cancer Services, Geelong, VIC, Australia., Collins IM; Department of Medical Oncology, Southwest HealthCare, Warrnambool and Deakin University, Geelong, VIC, Australia., Steer C; Border Medical Oncology, Albury Wodonga Regional Cancer Centre, Albury NSW, Australia and UNSW School of Clinical Medicine, Rural Clinical Campus, Albury, NSW, Australia., Warren M; Department of Medical Oncology, Bendigo Health, Bendigo, VIC, Australia., Karanth N; Division of Medicine, Alan Walker Cancer Centre, Darwin, NT, Australia., Xu H; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Fellowes A; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Hicks RJ; The St Vincent's Hospital Department of Medicine, University of Melbourne, Melbourne, VIC, Australia., Stewart KP; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Shale C; Hartwig Medical Foundation, Sydney, NSW, Australia., Priestley P; Hartwig Medical Foundation, Sydney, NSW, Australia., Dawson SJ; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Vissers JHA; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Fox SB; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Schofield P; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Department of Psychology, and Iverson Health Innovation Research Institute, Swinburne University, Melbourne, VIC, Australia.; School of Computing, Engineering and Mathematical Sciences, La Trobe University, Melbourne, VIC, Australia., Bowtell D; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Hofmann O; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Grimmond SM; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia., Mileshkin L; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Tothill RW; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.
Source: Nature communications [Nat Commun] 2025 May 20; Vol. 16 (1), pp. 4422. Date of Electronic Publication: 2025 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary.
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  Data: <searchLink fieldCode="AU" term="%22Rebello+RJ%22">Rebello RJ</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Posner+A%22">Posner A</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dong+R%22">Dong R</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Prall+OWJ%22">Prall OWJ</searchLink>; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sivakumaran+T%22">Sivakumaran T</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; 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The Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Medical Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Department of Medical Oncology, Barwon Health Cancer Services, Geelong, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Collins+IM%22">Collins IM</searchLink>; Department of Medical Oncology, Southwest HealthCare, Warrnambool and Deakin University, Geelong, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Steer+C%22">Steer C</searchLink>; Border Medical Oncology, Albury Wodonga Regional Cancer Centre, Albury NSW, Australia and UNSW School of Clinical Medicine, Rural Clinical Campus, Albury, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Warren+M%22">Warren M</searchLink>; Department of Medical Oncology, Bendigo Health, Bendigo, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Karanth+N%22">Karanth N</searchLink>; Division of Medicine, Alan Walker Cancer Centre, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fellowes+A%22">Fellowes A</searchLink>; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hicks+RJ%22">Hicks RJ</searchLink>; The St Vincent's Hospital Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Stewart+KP%22">Stewart KP</searchLink>; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Shale+C%22">Shale C</searchLink>; Hartwig Medical Foundation, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Priestley+P%22">Priestley P</searchLink>; Hartwig Medical Foundation, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dawson+SJ%22">Dawson SJ</searchLink>; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Vissers+JHA%22">Vissers JHA</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fox+SB%22">Fox SB</searchLink>; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schofield+P%22">Schofield P</searchLink>; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Department of Psychology, and Iverson Health Innovation Research Institute, Swinburne University, Melbourne, VIC, Australia.; School of Computing, Engineering and Mathematical Sciences, La Trobe University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bowtell+D%22">Bowtell D</searchLink>; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hofmann+O%22">Hofmann O</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Grimmond+SM%22">Grimmond SM</searchLink>; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mileshkin+L%22">Mileshkin L</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tothill+RW%22">Tothill RW</searchLink>; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.
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