Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation.
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| Title: | Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation. |
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| Authors: | Kirmani S; Framingham Heart Study, Framingham, MA, 01702, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Huan T; Framingham Heart Study, Framingham, MA, 01702, USA. Tianxiao.huan@nih.gov.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Tianxiao.huan@nih.gov., Van Amburg JC; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Joehanes R; Framingham Heart Study, Framingham, MA, 01702, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Uddin MM; Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA., Nguyen NQH; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Yu B; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Bressler J; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA., Ong DA; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Puddu F; Biomodal, The Trinity Building, Chesterford Research Park, Cambridge, CB10 1XL, UK., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, 98101, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Natarajan P; Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Conneely KN; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Weinstock JS; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Lange LA; Department of Medicine, University of Colorado at Denver, Aurora, CO, 80045, USA., Ferrier K; Department of Medicine, University of Colorado at Denver, Aurora, CO, 80045, USA., Heard-Costa NL; Framingham Heart Study, Framingham, MA, 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA., Murabito J; Framingham Heart Study, Framingham, MA, 01702, USA.; Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, 02118, USA., Bick AG; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Alexander.bick@vumc.org., Levy D; Framingham Heart Study, Framingham, MA, 01702, USA. Levyd@nih.gov.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Levyd@nih.gov. |
| Source: | Nature communications [Nat Commun] 2025 May 20; Vol. 16 (1), pp. 4678. Date of Electronic Publication: 2025 May 20. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59333-w |
