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Synthesis, in vitro and in silico studies of a novel chrysin-ferrocene Schiff base with potent anticancer activity via G1 arrest, caspase-dependent apoptosis and inhibition of topoisomerase II.

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Title: Synthesis, in vitro and in silico studies of a novel chrysin-ferrocene Schiff base with potent anticancer activity via G1 arrest, caspase-dependent apoptosis and inhibition of topoisomerase II.
Authors: Break MKB; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.; Medical and Diagnostic Research Centre, University of Ha'il, Ha'il, Saudi Arabia., Ansari SA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Katamesh AA; Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Albadari N; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Alshammari MD; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2501377. Date of Electronic Publication: 2025 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis, in vitro and in silico studies of a novel chrysin-ferrocene Schiff base with potent anticancer activity via G1 arrest, caspase-dependent apoptosis and inhibition of topoisomerase II.
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  Data: <searchLink fieldCode="AU" term="%22Break+MKB%22">Break MKB</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.; Medical and Diagnostic Research Centre, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ansari+SA%22">Ansari SA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Katamesh+AA%22">Katamesh AA</searchLink>; Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Albadari+N%22">Albadari N</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alshammari+MD%22">Alshammari MD</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alkahtani+HM%22">Alkahtani HM</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2501377. <i>Date of Electronic Publication: </i>2025 May 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1080/14756366.2025.2501377
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              Text: 2025 Dec
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