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PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer.

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Title: PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer.
Authors: Rademaker G; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Hernandez GA; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Seo Y; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Dahal S; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Miller-Phillips L; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany., Li AL; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA., Peng XL; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Luan C; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Qiu L; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Liegeois MA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Wang B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Wen KW; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Kim GE; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Collisson EA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kruger SF; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany., Boeck S; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany., Ormanns S; Institute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.; Innpath Institute for Pathology, Tirol Kliniken, Innsbruck, Austria., Guenther M; Institute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.; Innpath Institute for Pathology, Tirol Kliniken, Innsbruck, Austria., Heinemann V; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany., Haas M; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany., Looney MR; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Yeh JJ; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Departments of Surgery and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zoncu R; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Perera RM; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.
Source: Nature [Nature] 2025 Jul; Vol. 643 (8074), pp. 1381-1390. Date of Electronic Publication: 2025 May 21.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Rademaker+G%22">Rademaker G</searchLink>; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+GA%22">Hernandez GA</searchLink>; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Seo+Y%22">Seo Y</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dahal+S%22">Dahal S</searchLink>; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miller-Phillips+L%22">Miller-Phillips L</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Li+AL%22">Li AL</searchLink>; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Peng+XL%22">Peng XL</searchLink>; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Luan+C%22">Luan C</searchLink>; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liegeois+MA%22">Liegeois MA</searchLink>; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+KW%22">Wen KW</searchLink>; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+GE%22">Kim GE</searchLink>; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Collisson+EA%22">Collisson EA</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kruger+SF%22">Kruger SF</searchLink>; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Boeck+S%22">Boeck S</searchLink>; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ormanns+S%22">Ormanns S</searchLink>; Institute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.; Innpath Institute for Pathology, Tirol Kliniken, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Guenther+M%22">Guenther M</searchLink>; Institute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.; Innpath Institute for Pathology, Tirol Kliniken, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Heinemann+V%22">Heinemann V</searchLink>; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Haas+M%22">Haas M</searchLink>; Department of Hematology/Oncology, LMU Klinikum, University of Munich Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Looney+MR%22">Looney MR</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yeh+JJ%22">Yeh JJ</searchLink>; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Departments of Surgery and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zoncu+R%22">Zoncu R</searchLink>; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perera+RM%22">Perera RM</searchLink>; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. rushika.perera@ucsf.edu.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. rushika.perera@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Jul; Vol. 643 (8074), pp. 1381-1390. <i>Date of Electronic Publication: </i>2025 May 21.
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