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Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure.

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Title: Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure.
Authors: Labar AS; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA., Ulrich BC; Department of Medicine, Massachusetts General Hospital, Boston, MA., Lovelace TC; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.; Joint CMU-Pitt PhD Program in Computation Biology, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA., Bain WG; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.; Veterans Affairs Pittsburgh Health System, Pittsburgh, PA., Shah FA; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.; Veterans Affairs Pittsburgh Health System, Pittsburgh, PA., White EB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Abe EA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Giacona F; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Alba GA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Thompson BT; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Schmidt EP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Zuchelkowski BE; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA., Evankovich JW; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA., Yang H; Tsinghua Medicine, Tsinghua University, Beijing, China., Ramanan R; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA., Murray H; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA., Haidar G; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Snyder ME; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Qin S; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA., Wang X; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA., Zhang Y; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Nouraie SM; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Dela Cruz C; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.; Veterans Affairs Pittsburgh Health System, Pittsburgh, PA., Turnquist HR; Departments of Surgery and Immunology, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA., Ray P; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA., Ray A; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA., Methé B; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA., Benos PV; Department of Epidemiology, University of Florida, Gainesville, FL., Morris A; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA., McVerry BJ; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA., Alladina J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA., Kitsios GD; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.; Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA.
Source: Critical care medicine [Crit Care Med] 2025 Aug 01; Vol. 53 (8), pp. e1567-e1580. Date of Electronic Publication: 2025 May 22.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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