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Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial.

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Title: Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial.
Authors: Hüttner FJ; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Thoracic Surgery, Klinikum Nürnberg, Prof.-Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany., Klotz R; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Study Center of the German Surgical Society (SDGC), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany., Giese NA; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany., Kong B; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany., Ahmed A; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Cancer Immunology and Cancer Immunotherapy, German Cancer Research Center, Heidelberg, Germany., Merz D; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany., Pöchmann A; Department of Cancer Immunology and Cancer Immunotherapy, German Cancer Research Center, Heidelberg, Germany.; Helmholtz Institute for Translational Oncology (HI-TRON), Mainz, Germany., Burghaus I; Coordination Centre for Clinical Trials (KKS), Medical Faculty & Heidelberg University Hospital, Heidelberg, Germany., Hackert T; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Strobel O; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria., Mihaljevic AL; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Transplantation Surgery, University Hospital Tübingen, Tübingen, Germany., Michalski CW; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany., Büchler MW; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Botton-Champalimaud Pancreatic Cancer, Champalimaud Foundation, Lisbon, Portugal., Diener MK; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany. markus.diener@klinikum-nuernberg.de.; Department of General, Visceral and Thoracic Surgery, Klinikum Nürnberg, Prof.-Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany. markus.diener@klinikum-nuernberg.de.
Source: Langenbeck's archives of surgery [Langenbecks Arch Surg] 2025 May 22; Vol. 410 (1), pp. 168. Date of Electronic Publication: 2025 May 22.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9808285 Publication Model: Electronic Cited Medium: Internet ISSN: 1435-2451 (Electronic) Linking ISSN: 14352443 NLM ISO Abbreviation: Langenbecks Arch Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial.
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  Data: <searchLink fieldCode="AU" term="%22Hüttner+FJ%22">Hüttner FJ</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Thoracic Surgery, Klinikum Nürnberg, Prof.-Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klotz+R%22">Klotz R</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Study Center of the German Surgical Society (SDGC), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Giese+NA%22">Giese NA</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kong+B%22">Kong B</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ahmed+A%22">Ahmed A</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Cancer Immunology and Cancer Immunotherapy, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Merz+D%22">Merz D</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pöchmann+A%22">Pöchmann A</searchLink>; Department of Cancer Immunology and Cancer Immunotherapy, German Cancer Research Center, Heidelberg, Germany.; Helmholtz Institute for Translational Oncology (HI-TRON), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Burghaus+I%22">Burghaus I</searchLink>; Coordination Centre for Clinical Trials (KKS), Medical Faculty & Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hackert+T%22">Hackert T</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strobel+O%22">Strobel O</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mihaljevic+AL%22">Mihaljevic AL</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Department of General, Visceral and Transplantation Surgery, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Michalski+CW%22">Michalski CW</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Büchler+MW%22">Büchler MW</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.; Botton-Champalimaud Pancreatic Cancer, Champalimaud Foundation, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Diener+MK%22">Diener MK</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany. markus.diener@klinikum-nuernberg.de.; Department of General, Visceral and Thoracic Surgery, Klinikum Nürnberg, Prof.-Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany. markus.diener@klinikum-nuernberg.de.
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  Data: <searchLink fieldCode="JN" term="%229808285%22">Langenbeck's archives of surgery</searchLink> [Langenbecks Arch Surg] 2025 May 22; Vol. 410 (1), pp. 168. <i>Date of Electronic Publication: </i>2025 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9808285 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-2451 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214352443%22">14352443 </searchLink><i>NLM ISO Abbreviation: </i>Langenbecks Arch Surg <i>Subsets: </i>MEDLINE
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