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Cardioprotection in patients with anthracycline-treated breast cancer: final analysis from the 2 × 2 randomized, placebo-controlled, double-blind SAFE trial.

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Title: Cardioprotection in patients with anthracycline-treated breast cancer: final analysis from the 2 × 2 randomized, placebo-controlled, double-blind SAFE trial.
Authors: Meattini I; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it., Becherini C; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Martella F; Oncology Department, Breast and Medical Oncology Units, Azienda USL Toscana Centro, Florence, Italy., Del Bene MR; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy., Saieva C; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy., Bacci C; Oncology Department, Breast and Medical Oncology Units, Azienda USL Toscana Centro, Florence, Italy., Coltelli L; Medical Oncology Unit, Livorno Hospital, Azienda USL Toscana Nord Ovest, Livorno, Italy., Pilato G; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy., Visani L; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Salvestrini V; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Francolini G; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Marrazzo L; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Oncology Department, Medical Physics Unit, Careggi University Hospital, Florence, Italy., Bernini M; Breast Surgery Unit, Careggi University Hospital, Florence, Italy., Orzalesi L; Breast Surgery Unit, Careggi University Hospital, Florence, Italy., Nori J; Diagnostic Senology Unit, Careggi University Hospital, Florence, Italy., Bianchi S; Department of Health Sciences, Division of Pathological Anatomy, University of Florence, Florence, Italy., Olivotto I; Department of Experimental and Clinical Medicine, Division of Physiology, University of Florence, Florence, Italy., Morandi A; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy., Curigliano G; Istituto Europeo di Oncologia, IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy. Electronic address: https://twitter.com/curijoey., Barletta G; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy., Livi L; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Source: ESMO open [ESMO Open] 2025 Jun; Vol. 10 (6), pp. 105116. Date of Electronic Publication: 2025 May 21.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cardioprotection in patients with anthracycline-treated breast cancer: final analysis from the 2 × 2 randomized, placebo-controlled, double-blind SAFE trial.
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  Data: <searchLink fieldCode="AU" term="%22Meattini+I%22">Meattini I</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it.<br /><searchLink fieldCode="AU" term="%22Becherini+C%22">Becherini C</searchLink>; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Martella+F%22">Martella F</searchLink>; Oncology Department, Breast and Medical Oncology Units, Azienda USL Toscana Centro, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Bene+MR%22">Del Bene MR</searchLink>; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Saieva+C%22">Saieva C</searchLink>; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bacci+C%22">Bacci C</searchLink>; Oncology Department, Breast and Medical Oncology Units, Azienda USL Toscana Centro, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Coltelli+L%22">Coltelli L</searchLink>; Medical Oncology Unit, Livorno Hospital, Azienda USL Toscana Nord Ovest, Livorno, Italy.<br /><searchLink fieldCode="AU" term="%22Pilato+G%22">Pilato G</searchLink>; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Visani+L%22">Visani L</searchLink>; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Salvestrini+V%22">Salvestrini V</searchLink>; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Francolini+G%22">Francolini G</searchLink>; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Marrazzo+L%22">Marrazzo L</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Oncology Department, Medical Physics Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bernini+M%22">Bernini M</searchLink>; Breast Surgery Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Orzalesi+L%22">Orzalesi L</searchLink>; Breast Surgery Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Nori+J%22">Nori J</searchLink>; Diagnostic Senology Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchi+S%22">Bianchi S</searchLink>; Department of Health Sciences, Division of Pathological Anatomy, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Olivotto+I%22">Olivotto I</searchLink>; Department of Experimental and Clinical Medicine, Division of Physiology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Morandi+A%22">Morandi A</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; Istituto Europeo di Oncologia, IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy. Electronic address: https://twitter.com/curijoey.<br /><searchLink fieldCode="AU" term="%22Barletta+G%22">Barletta G</searchLink>; Diagnostic Cardiology, CardioThoracic and Vascular Department, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Livi+L%22">Livi L</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy; Radiation Oncology and Breast Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2025 Jun; Vol. 10 (6), pp. 105116. <i>Date of Electronic Publication: </i>2025 May 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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