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Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling.

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Title: Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling.
Authors: Wu SM; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Chen KY; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chuang HC; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan., Ho SC; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lin CW; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei, Taiwan.; International PhD Program for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan., Han CL; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan., Sun WL; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Feng PH; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Lin SF; Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Chen YH; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Chen TT; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Tseng CH; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Liu WT; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan., Lee KY; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan leekangyun@tmu.edu.tw.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Source: The European respiratory journal [Eur Respir J] 2025 Sep 17; Vol. 66 (3). Date of Electronic Publication: 2025 Sep 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
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  Data: Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling.
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  Data: <searchLink fieldCode="AU" term="%22Wu+SM%22">Wu SM</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+KY%22">Chen KY</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+HC%22">Chuang HC</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+SC%22">Ho SC</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CW%22">Lin CW</searchLink>; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei, Taiwan.; International PhD Program for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Han+CL%22">Han CL</searchLink>; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sun+WL%22">Sun WL</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feng+PH%22">Feng PH</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SF%22">Lin SF</searchLink>; Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YH%22">Chen YH</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TT%22">Chen TT</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+CH%22">Tseng CH</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+WT%22">Liu WT</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KY%22">Lee KY</searchLink>; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan leekangyun@tmu.edu.tw.; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Thoracic Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%228803460%22">The European respiratory journal</searchLink> [Eur Respir J] 2025 Sep 17; Vol. 66 (3). <i>Date of Electronic Publication: </i>2025 Sep 17 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22European+Respiratory+Society%22">European Respiratory Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8803460 <i>Publication Model: </i>Electronic-Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1399-3003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209031936%22">09031936 </searchLink><i>NLM ISO Abbreviation: </i>Eur Respir J <i>Subsets: </i>MEDLINE
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        Value: 10.1183/13993003.01610-2024
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