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Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity.

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Title: Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity.
Authors: Bouazza N; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Unité de Recherche Clinique Necker Cochin, AP-HP, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France., Semeraro M; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France., Lui G; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France., Froelicher-Bournaud L; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France., Choupeaux L; Unité de Recherche Clinique Necker Cochin, AP-HP, France., Treluyer JM; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Unité de Recherche Clinique Necker Cochin, AP-HP, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France., Benaboud S; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France., Terzic J; Nephrology Dialysis Transplantation Children's Unit, University Hospital Hautepierre, Strasbourg, France., Hachulla E; Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, CERAINOM, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France., Remy P; Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare «Syndrome Néphrotique Idiopathique», Fédération Hospitalo-Universitaire 'Innovative Therapy for Immune Disorders', Créteil, France., Harambat J; Pediatric Nephrology Unit, Reference Center for Rare Kidney Diseases, SORARE, Bordeaux University Hospital, Bordeaux, France., Karras A; Department of Nephrology, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Université Paris Cité, Unité de Formation et de Recherche de Médecine, Paris, France., Rousset-Rouviere C; Service de pédiatrie multidisciplinaire, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France., Jolivot A; Service de néphrologie, Hospices civils de Lyon, Hôpital Édouard Herriot, Lyon, France., Amoura Z; Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France., Daugas E; Service de Néphrologie, Assistance publique - Hôpitaux de Paris (AP-HP), Hôpital Bichat-Claude Bernard, Paris, France., Hummel A; Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France., Salomon R; Pediatric Nephrology, Inserm U1163, MARHEA Reference Center, Imagine Institute, Paris Cité University, Necker-Enfants Malades Hospital, APHP, Paris, France., Lega JC; Department of Internal and Vascular Medicine, Hospices Civils de Lyon, Lyon, France., Decramer S; Department of Pediatric Internal Medicine, Rheumatology and Nephrology, Toulouse University Hospital, Toulouse, France., Belot A; Pediatric Rheumatology, Nephrology, Dermatology Department, CMR RAISE, Women-Mother-Child Hospital, Hospices Civils de Lyon, Bron, France., Gobert D; Sorbonne Université, service de médecine interne, AP-HP, Hôpital universitaire Saint Antoine, Paris, France., Costedoat-Chalumeau N; Centre de référence maladies auto-immunes et systémiques rares de l'île de France, Cochin Hospital, Paris, France., Faguer S; Department of Nephrology and Organ Transplantation, University Hospital of Toulouse, French Intensive Care Renal Network, Toulouse, France., Melki I; General Paediatrics, Department of Infectious Disease and Internal Medicine, Robert Debré University Hospital, APHP, Nord-Université Paris Cité, Paris, France., Jourde-Chiche N; Department of Nephrology, AP-, Marseille, HM, France., Bader-Meunier B; Department of Pediatric Immunology, Hematology and Rheumatology, Necker Hospital, AP-HP, National Reference Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Institut IMAGINE, Paris, France.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Oct; Vol. 91 (10), pp. 2854-2864. Date of Electronic Publication: 2025 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity.
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  Data: <searchLink fieldCode="AU" term="%22Bouazza+N%22">Bouazza N</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Unité de Recherche Clinique Necker Cochin, AP-HP, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.<br /><searchLink fieldCode="AU" term="%22Semeraro+M%22">Semeraro M</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lui+G%22">Lui G</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France.<br /><searchLink fieldCode="AU" term="%22Froelicher-Bournaud+L%22">Froelicher-Bournaud L</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France.<br /><searchLink fieldCode="AU" term="%22Choupeaux+L%22">Choupeaux L</searchLink>; Unité de Recherche Clinique Necker Cochin, AP-HP, France.<br /><searchLink fieldCode="AU" term="%22Treluyer+JM%22">Treluyer JM</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Unité de Recherche Clinique Necker Cochin, AP-HP, France.; CIC-1419 Inserm, Cochin-Necker, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France.<br /><searchLink fieldCode="AU" term="%22Benaboud+S%22">Benaboud S</searchLink>; Université Paris Cité, Inserm, Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, Paris, France.; Service de Pharmacologie Clinique, Hôpital Cochin, AP-HP, Groupe Hospitalier Paris Centre, France.<br /><searchLink fieldCode="AU" term="%22Terzic+J%22">Terzic J</searchLink>; Nephrology Dialysis Transplantation Children's Unit, University Hospital Hautepierre, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Hachulla+E%22">Hachulla E</searchLink>; Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, CERAINOM, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France.<br /><searchLink fieldCode="AU" term="%22Remy+P%22">Remy P</searchLink>; Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare «Syndrome Néphrotique Idiopathique», Fédération Hospitalo-Universitaire 'Innovative Therapy for Immune Disorders', Créteil, France.<br /><searchLink fieldCode="AU" term="%22Harambat+J%22">Harambat J</searchLink>; Pediatric Nephrology Unit, Reference Center for Rare Kidney Diseases, SORARE, Bordeaux University Hospital, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Karras+A%22">Karras A</searchLink>; Department of Nephrology, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Université Paris Cité, Unité de Formation et de Recherche de Médecine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rousset-Rouviere+C%22">Rousset-Rouviere C</searchLink>; Service de pédiatrie multidisciplinaire, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Jolivot+A%22">Jolivot A</searchLink>; Service de néphrologie, Hospices civils de Lyon, Hôpital Édouard Herriot, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Amoura+Z%22">Amoura Z</searchLink>; Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Daugas+E%22">Daugas E</searchLink>; Service de Néphrologie, Assistance publique - Hôpitaux de Paris (AP-HP), Hôpital Bichat-Claude Bernard, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hummel+A%22">Hummel A</searchLink>; Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France.<br /><searchLink fieldCode="AU" term="%22Salomon+R%22">Salomon R</searchLink>; Pediatric Nephrology, Inserm U1163, MARHEA Reference Center, Imagine Institute, Paris Cité University, Necker-Enfants Malades Hospital, APHP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lega+JC%22">Lega JC</searchLink>; Department of Internal and Vascular Medicine, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Decramer+S%22">Decramer S</searchLink>; Department of Pediatric Internal Medicine, Rheumatology and Nephrology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Belot+A%22">Belot A</searchLink>; Pediatric Rheumatology, Nephrology, Dermatology Department, CMR RAISE, Women-Mother-Child Hospital, Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Gobert+D%22">Gobert D</searchLink>; Sorbonne Université, service de médecine interne, AP-HP, Hôpital universitaire Saint Antoine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Costedoat-Chalumeau+N%22">Costedoat-Chalumeau N</searchLink>; Centre de référence maladies auto-immunes et systémiques rares de l'île de France, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Faguer+S%22">Faguer S</searchLink>; Department of Nephrology and Organ Transplantation, University Hospital of Toulouse, French Intensive Care Renal Network, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Melki+I%22">Melki I</searchLink>; General Paediatrics, Department of Infectious Disease and Internal Medicine, Robert Debré University Hospital, APHP, Nord-Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jourde-Chiche+N%22">Jourde-Chiche N</searchLink>; Department of Nephrology, AP-, Marseille, HM, France.<br /><searchLink fieldCode="AU" term="%22Bader-Meunier+B%22">Bader-Meunier B</searchLink>; Department of Pediatric Immunology, Hematology and Rheumatology, Necker Hospital, AP-HP, National Reference Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Institut IMAGINE, Paris, France.
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