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A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry.

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Title: A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry.
Authors: Park KC; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK., Jaafari AM; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK., Smith CA; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Lobo AR; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Errichelli L; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Şimşek G; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK; Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Türkiye., Gunadasa-Rohling M; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK., Marchant A; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Levitin MO; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Castilla-Llorente V; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Vilela P; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK., Swietach P; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK. Electronic address: swietach@dpag.ox.ac.uk.
Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2025 Jul; Vol. 204, pp. 89-100. Date of Electronic Publication: 2025 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry.
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  Data: <searchLink fieldCode="AU" term="%22Park+KC%22">Park KC</searchLink>; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.<br /><searchLink fieldCode="AU" term="%22Jaafari+AM%22">Jaafari AM</searchLink>; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.<br /><searchLink fieldCode="AU" term="%22Smith+CA%22">Smith CA</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Lobo+AR%22">Lobo AR</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Errichelli+L%22">Errichelli L</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Şimşek+G%22">Şimşek G</searchLink>; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK; Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Gunadasa-Rohling+M%22">Gunadasa-Rohling M</searchLink>; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.<br /><searchLink fieldCode="AU" term="%22Marchant+A%22">Marchant A</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Levitin+MO%22">Levitin MO</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Castilla-Llorente+V%22">Castilla-Llorente V</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Vilela+P%22">Vilela P</searchLink>; Evox Therapeutics, Medawar Centre, Robert Robinson Ave, Oxford OX4 4HG, UK.<br /><searchLink fieldCode="AU" term="%22Swietach+P%22">Swietach P</searchLink>; Department of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK. Electronic address: swietach@dpag.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220262322%22">Journal of molecular and cellular cardiology</searchLink> [J Mol Cell Cardiol] 2025 Jul; Vol. 204, pp. 89-100. <i>Date of Electronic Publication: </i>2025 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0262322 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8584 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222828%22">00222828 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul
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