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Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.

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Title: Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Authors: Kubeš J; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Karabanovich G; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Cong ATQ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 55905, MN, USA., Melnikova I; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Lenčová O; Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Kollárová P; Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Bavlovič Piskáčková H; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Keresteš V; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Applová L; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Arrouye LCM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA., Alvey JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA., Paluncic J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA., Witter TL; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 55905, MN, USA., Jirkovská A; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Kuneš J; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Štěrbová-Kovaříková P; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic., Austin CA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. caroline.austin@newcastle.ac.uk., Štěrba M; Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic. sterbam@lfhk.cuni.cz., Šimůnek T; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic. simunekt@faf.cuni.cz., Roh J; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University; Hradec, Králové, 500 03, Czech Republic. rohj@faf.cuni.cz., Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 55905, MN, USA. schellenberg.matthew@mayo.edu.
Source: Nature communications [Nat Commun] 2025 May 28; Vol. 16 (1), pp. 4928. Date of Electronic Publication: 2025 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60167-9