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Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

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Title: Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.
Authors: Furqan M; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Elliott RJR; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Nagle PWK; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Dawson JC; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Masalmeh R; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Garcia VA; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Munro AF; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Drake C; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Morrison GM; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., Pollard SM; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., Ebner D; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, UK., Brunton VG; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Frame MC; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK., Carragher NO; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.
Source: Pharmaceutics [Pharmaceutics] 2025 Apr 23; Vol. 17 (5). Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Furqan+M%22">Furqan M</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+RJR%22">Elliott RJR</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Nagle+PWK%22">Nagle PWK</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Dawson+JC%22">Dawson JC</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Masalmeh+R%22">Masalmeh R</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+VA%22">Garcia VA</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Munro+AF%22">Munro AF</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Drake+C%22">Drake C</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Morrison+GM%22">Morrison GM</searchLink>; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+SM%22">Pollard SM</searchLink>; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Ebner+D%22">Ebner D</searchLink>; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Brunton+VG%22">Brunton VG</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Frame+MC%22">Frame MC</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.<br /><searchLink fieldCode="AU" term="%22Carragher+NO%22">Carragher NO</searchLink>; Edinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.; Cancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.
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