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WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.

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Title: WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.
Authors: Trzeciak AJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. trzeciaa@mskcc.org., Liu ZL; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gatie M; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Krebs AS; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Saitz Rojas W; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., O'Neal AJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Baako AK; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Wang Z; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Nelson J; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Miranda IC; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Uddin J; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA., Lipshutz A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xie J; Department of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Huang CL; Department of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Saavedra PHV; Department of Biology, Northeastern University, Boston, MA, USA., Hadjantonakis AK; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Overholtzer M; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Glickman MS; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA.; Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Subramanya AR; Dept of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Vierbuchen T; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Etchegaray JI; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Lucas CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, BioQuarter, UK.; Institute for Regeneration and Repair, Edinburgh, BioQuarter, UK., Parkhurst CN; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Perry JSA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA. perryj@mskcc.org.
Source: Nature communications [Nat Commun] 2025 May 28; Vol. 16 (1), pp. 4945. Date of Electronic Publication: 2025 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Trzeciak+AJ%22">Trzeciak AJ</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. trzeciaa@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Liu+ZL%22">Liu ZL</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gatie+M%22">Gatie M</searchLink>; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Krebs+AS%22">Krebs AS</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saitz+Rojas+W%22">Saitz Rojas W</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22O'Neal+AJ%22">O'Neal AJ</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Baako+AK%22">Baako AK</searchLink>; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+J%22">Nelson J</searchLink>; Louis V. 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Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Overholtzer+M%22">Overholtzer M</searchLink>; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Glickman+MS%22">Glickman MS</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. 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Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA. perryj@mskcc.org.
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