WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.
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| Title: | WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity. |
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| Authors: | Trzeciak AJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. trzeciaa@mskcc.org., Liu ZL; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gatie M; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Krebs AS; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Saitz Rojas W; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., O'Neal AJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Baako AK; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Wang Z; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA., Nelson J; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Miranda IC; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Uddin J; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA., Lipshutz A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xie J; Department of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Huang CL; Department of Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Saavedra PHV; Department of Biology, Northeastern University, Boston, MA, USA., Hadjantonakis AK; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Overholtzer M; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Glickman MS; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA.; Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Subramanya AR; Dept of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Vierbuchen T; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Etchegaray JI; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Lucas CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, BioQuarter, UK.; Institute for Regeneration and Repair, Edinburgh, BioQuarter, UK., Parkhurst CN; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Perry JSA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY, USA. perryj@mskcc.org. |
| Source: | Nature communications [Nat Commun] 2025 May 28; Vol. 16 (1), pp. 4945. Date of Electronic Publication: 2025 May 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59901-0 |
