Pharmacological Enhancement of Small Conductance Ca2+-Activated K+ Channels Suppresses Cardiac Arrhythmias in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.

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Title: Pharmacological Enhancement of Small Conductance Ca2+-Activated K+ Channels Suppresses Cardiac Arrhythmias in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
Authors: Veress R; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Terentyeva R; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Belevych AE; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Perger F; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Nichtova Z; Department of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.)., Pokrass A; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Cheng Y; Food Science and Human Nutrition Department, University of Florida, Gainesville (Y.C., B.L.)., Chorna S; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Deschenes I; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Gyorke S; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Knollmann BC; Department of Medicine, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical School, Nashville, TN (B.C.K.)., Clements RT; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island College of Pharmacy, Kingston (R.T.C.).; Department of Medicine, Providence VAMC and Brown University, RI (R.T.C.)., Singh H; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.)., Liu B; Food Science and Human Nutrition Department, University of Florida, Gainesville (Y.C., B.L.)., Csordas G; Department of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.)., Hamilton S; Department of Cellular and Molecular Medicine, University of Arizona, Tucson (S.H.)., Terentyev D; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).
Source: Circulation research [Circ Res] 2025 Jul 18; Vol. 137 (3), pp. 386-399. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
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  Data: Pharmacological Enhancement of Small Conductance Ca<superscript>2+</superscript>-Activated K<superscript>+</superscript> Channels Suppresses Cardiac Arrhythmias in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
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  Data: <searchLink fieldCode="AU" term="%22Veress+R%22">Veress R</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).<br /><searchLink fieldCode="AU" term="%22Terentyeva+R%22">Terentyeva R</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. 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Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).<br /><searchLink fieldCode="AU" term="%22Knollmann+BC%22">Knollmann BC</searchLink>; Department of Medicine, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical School, Nashville, TN (B.C.K.).<br /><searchLink fieldCode="AU" term="%22Clements+RT%22">Clements RT</searchLink>; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island College of Pharmacy, Kingston (R.T.C.).; Department of Medicine, Providence VAMC and Brown University, RI (R.T.C.).<br /><searchLink fieldCode="AU" term="%22Singh+H%22">Singh H</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).; Dorothy M. 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Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (R.V., R.T., A.E.B., F.P., A.P., S.C., I.D., S.G., H.S., D.T.).
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