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Efficacy of RTS,S/AS01E Only Seen in Baseline Parasitemic and Not Baseline Aparasitemic Plasmodium falciparum-Exposed, Drug-Treated Kenyan Adults.

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Title: Efficacy of RTS,S/AS01E Only Seen in Baseline Parasitemic and Not Baseline Aparasitemic Plasmodium falciparum-Exposed, Drug-Treated Kenyan Adults.
Authors: Copeland NK; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Otieno L; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Otieno JD; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Otieno S; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Chira S; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Ivinson K; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Onyango I; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Wasuna R; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Akala H; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Onditi A; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Sifuna P; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Andagalu B; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Oyugi R; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Omondi M; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Amoit S; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya., Locke E; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Gregory S; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Bergmann-Leitner ES; Biologics Research & Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Pindolia H; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom., Raine M; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Gast C; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Mercer LD; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Aponte JJ; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Lievens M; Vaccine Clinical R&D, GlaxoSmithKline, Wavre, Belgium., Ockenhouse CF; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland., Lee CK; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.
Source: The Journal of infectious diseases [J Infect Dis] 2025 Sep 15; Vol. 232 (3), pp. e372-e382.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of RTS,S/AS01E Only Seen in Baseline Parasitemic and Not Baseline Aparasitemic Plasmodium falciparum-Exposed, Drug-Treated Kenyan Adults.
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  Data: <searchLink fieldCode="AU" term="%22Copeland+NK%22">Copeland NK</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+L%22">Otieno L</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+JD%22">Otieno JD</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+S%22">Otieno S</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Chira+S%22">Chira S</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ivinson+K%22">Ivinson K</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Onyango+I%22">Onyango I</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Wasuna+R%22">Wasuna R</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Akala+H%22">Akala H</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Onditi+A%22">Onditi A</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Sifuna+P%22">Sifuna P</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Andagalu+B%22">Andagalu B</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Oyugi+R%22">Oyugi R</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Omondi+M%22">Omondi M</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Amoit+S%22">Amoit S</searchLink>; Kombewa Clinical Research Centre, Kenya Medical Research Institute/US Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Locke+E%22">Locke E</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gregory+S%22">Gregory S</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bergmann-Leitner+ES%22">Bergmann-Leitner ES</searchLink>; Biologics Research & Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Pindolia+H%22">Pindolia H</searchLink>; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Raine+M%22">Raine M</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gast+C%22">Gast C</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mercer+LD%22">Mercer LD</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aponte+JJ%22">Aponte JJ</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lievens+M%22">Lievens M</searchLink>; Vaccine Clinical R&D, GlaxoSmithKline, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Ockenhouse+CF%22">Ockenhouse CF</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lee+CK%22">Lee CK</searchLink>; Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia, USA; Seattle, Washington, USA; Nairobi, Kenya; and Geneva, Switzerland.
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