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A pragmatic, multicenter, randomized trial comparing morning versus evening dosing of adjuvant endocrine therapy (REaCT-CHRONO Study).

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Title: A pragmatic, multicenter, randomized trial comparing morning versus evening dosing of adjuvant endocrine therapy (REaCT-CHRONO Study).
Authors: Savard MF; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada. msavard@toh.ca.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. msavard@toh.ca., Ibrahim M; Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada., Saunders D; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Pond GR; Department of Oncology, McMaster University, Hamilton, NY, Canada., Ng TL; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Awan AA; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Sehdev S; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Alqahtani N; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada., Vandermeer L; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., MacDonald F; Ottawa Hospital Cancer Centre, Ottawa, ON, Canada., Beltran-Bless AA; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Fallowfield L; SHORE-C, Brighton & Sussex Medical School, University of Sussex, Farmer, UK., Clemons M; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Source: NPJ breast cancer [NPJ Breast Cancer] 2025 May 29; Vol. 11 (1), pp. 49. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Savard+MF%22">Savard MF</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada. msavard@toh.ca.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. msavard@toh.ca.<br /><searchLink fieldCode="AU" term="%22Ibrahim+M%22">Ibrahim M</searchLink>; Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Saunders+D%22">Saunders D</searchLink>; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pond+GR%22">Pond GR</searchLink>; Department of Oncology, McMaster University, Hamilton, NY, Canada.<br /><searchLink fieldCode="AU" term="%22Ng+TL%22">Ng TL</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Awan+AA%22">Awan AA</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Sehdev+S%22">Sehdev S</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Alqahtani+N%22">Alqahtani N</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Vandermeer+L%22">Vandermeer L</searchLink>; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22MacDonald+F%22">MacDonald F</searchLink>; Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Beltran-Bless+AA%22">Beltran-Bless AA</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fallowfield+L%22">Fallowfield L</searchLink>; SHORE-C, Brighton & Sussex Medical School, University of Sussex, Farmer, UK.<br /><searchLink fieldCode="AU" term="%22Clemons+M%22">Clemons M</searchLink>; Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
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